Preclinical evidence suggests that T4 can promote tumor growth while T3 can act conversely; therefore, the fT3 and fT4 concentrations should affect overall survival (OS) in cancer patients. The objective of the study was to look for an association between thyroid hormone concentrations in peripheral blood and OS in the pancreatic adenocarcinoma (PDAC) patients group. We included, retrospectively, 15 PDAC patients, without thyroid dysfunction under treatment, who underwent radical surgery, with no prior history of anticancer therapy. TSH, fT3, and fT4 concentrations were determined in blood samples taken preoperatively. We found that the fT3/fT4 ratio categorized into two groups (<0.22 vs. ≥0.22) dichotomized the study population into poor and good prognosis subgroups (log-rank p = 0.03; OS medians, respectively: 3 and 14 months), being a statistically significant predictor both in uni- and multivariate Cox regression analysis. We conclude that the importance of fT4 into fT3 conversion means not just its standard metabolic effects as the final products of thyroid gland activity. We hypothesize that it is linked to the progression of pancreatic malignancies, either via thyroid hormone receptors or indirectly, by interaction with cancer cells product.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856112 | PMC |
| http://dx.doi.org/10.3390/biomedicines11010077 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Public Health.
Alzheimers Dement
December 2024
Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.
Background: Overt hyperthyroidism and hypothyroidism are regarded as possible causes of reversible dementia. Evidence on the risk of dementia associated with subclinical thyroid dysfunctions is limited and barely existent in the very old, while findings are conflicting.
Objective: To cross-sectionally and longitudinally investigate the association of subclinical-hyperthyroidism and subclinical-hypothyroidism with dementia in a prospective population-based study of 80-years or older residents in Varese province, Italy (Monzino 80-plus Study).
QRFP43 modulates the activity of the hypothalamic-pituitary-thyroid axis in female sheep.
Sci Rep
January 2025
Department of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, Jabłonna, 05-110, Poland.
Since the early discovery of QRFP43, intensive research has been primarily focused on its role in the modulation of food intake. As is widely recognised, the regulation of the body's energy status is a highly complex process involving numerous systems, hormones and neurotransmitters. Among the most important regulators of energy status, alongside the satiety and hunger centre located in the hypothalamus, is the HPT axis, which directly and indirectly affects the regulation of metabolism in all cells of the body.
View Article and Find Full Text PDFAssociation between night eating frequency and thyroid function and sensitivity: a cross-sectional study from the NHANES database.
Front Endocrinol (Lausanne)
January 2025
Department of Gastrointestinal Surgery, General Surgery, Xichang People's Hospital, Xichang, China.
Thyroid function is closely linked to circadian rhythms, but the relationship between the frequency of night eating and thyroid function remains unclear. Our study aimed to investigate the association between night eating frequency and its impact on thyroid function and sensitivity. This study included 6093 participants from the U.
View Article and Find Full Text PDFDetection rate and clinical characteristics of coexisting autoimmune diseases in children with Graves' disease: a single-center study from China.
Endocrine
January 2025
Department of Endocrinology, Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Purpose: This study aimed to determine the detection rate of autoimmune polyendocrine syndrome (APS) among children with Graves' disease (GD) at a single center and to compare clinical characteristics between those with isolated GD and those GD with APS (APS-GD).
Methods: A retrospective analysis was conducted on the clinical data of 555 patients and were categorized into isolated GD and APS-GD groups based on their progression status. The time for FT to return to normal was used as an indicator of short-term treatment effectiveness.
Stimulated Thyrotropin (TSH) Levels Were Inversely Correlated with Age.
Int J Gen Med
December 2024
Department of Geriatric Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, People's Republic of China.
Article Synopsis
- The study examined how aging affects serum Thyrotropin (TSH) levels while considering thyroid-related factors.
- Researchers analyzed data from 343 patients who had thyroid surgery and underwent levothyroxine (LT4) treatment, categorized into young, middle-aged, and elderly groups.
- Results indicated that after withdrawal of LT4, older individuals had significantly lower stimulated TSH levels compared to younger groups, suggesting an important relationship between aging and TSH regulation.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!