A tumor is not just comprised of cancer cells but also a heterogeneous group of infiltrating and resident host cells, as well as their secreted factors that form the extracellular matrix [...].
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| http://dx.doi.org/10.3390/cancers15020501 | DOI Listing |
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Multiple myeloma-associated non-crystalline proximal tubulopathy and crystalline cast nephropathy: Biochemical and structural features of disease-causing monoclonal kappa light chains.
FASEB J
January 2025
Department of Hematology, Nephrology, and Rheumatology, Graduate School of Medicine, Akita University, Akita, Japan.
Various tubular diseases in patients with multiple myeloma (MM) are caused by monoclonal immunoglobulin light chains (LCs). However, the physicochemical characteristics of the disease-causing LCs contributing to the onset of MM-associated tubular diseases remain unclear. We herein report a rare case of MM-associated combined tubulopathies: non-crystalline light chain proximal tubulopathy (LCPT) and crystalline light chain cast nephropathy (LCCN).
View Article and Find Full Text PDFEyelid Spindle Cell Lipoma: Case Report and Review of Three Patients in Literature.
Clin Case Rep
January 2025
Department of Pathology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama University Okayama Japan.
A 39-year-old woman presented a saucer-shaped mass in the left upper eyelid and underwent the extirpation at local anesthesia. Pathologically, collagen fibers, capillaries, small vessels, and CD34-positive spindle cells were dispersed among mature adipose tissues, indicative of spindle cell lipoma. Long-lasting cyst-like eyelid masses would be usually dermoid cysts, and spindle cell lipoma would be listed as a rare pathological diagnosis in differential diagnoses of cyst-like lesions in the upper and lower eyelid.
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Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, VIC, 3084, Australia.
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BMC Cancer
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Finetech in Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran.
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Saudi Med J
January 2025
From the Department of Family and Community Medicine (Alsaidan, Thirunavukkarasu), College of Medicine, Jouf University, Aljouf; and from the Department of Public Health (Alsulami), Maternity and Children Hospital, Makkah, Kingdom of Saudi Arabia.
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