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http://dx.doi.org/10.1111/php.13761 | DOI Listing |
Clin Mol Hepatol
January 2025
Department of internal medicine and liver research institute, Seoul national university hospital, Seoul national university college of medicine, Seoul, Korea.
Hum Vaccin Immunother
January 2024
Acquisitions Editor, Taylor & Francis Group
Ann Transl Med
December 2024
Medical Direction, Rovereto Hospital, Provincial Agency for Social and Sanitary Services (APSS), Trento, Italy.
JACC Adv
December 2024
Department of Neurology, National Cerebral and Cardiovascular Center (NCVC), Suita, Osaka, Japan.
Front Parasitol
December 2023
Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Reticulocyte Binding Protein Homologue (RH5), a leading malaria vaccine candidate, is essential for erythrocyte invasion by the parasite, interacting with the human host receptor, basigin. RH5 has a small number of polymorphisms relative to other blood-stage antigens, and studies have shown that vaccine-induced antibodies raised against RH5 are strain-transcending, however most studies investigating RH5 diversity have been done in Africa. Understanding the genetic diversity and evolution of malaria antigens in other regions is important for their validation as vaccine candidates.
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