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[F]FET-PET in children and adolescents with central nervous system tumors: does it support difficult clinical decision-making? | LitMetric

AI Article Synopsis

  • Scientists studied a type of brain imaging called [F]FET-PET to help understand brain tumors in kids and teenagers.
  • They looked at 21 patients aged 1 to 19 years who had brain tumors, using [F]FET-PET along with other tests.
  • The results showed that this type of imaging helped doctors make better decisions for 14 out of 21 patients, like avoiding unnecessary surgery or changing treatments.

Article Abstract

Purpose: Positron emission tomography (PET) with O-(2-[F]fluoroethyl)-L-tyrosine ([F]FET) is a well-established tool for non-invasive assessment of adult central nervous system (CNS) tumors. However, data on its diagnostic utility and impact on clinical management in children and adolescents are limited.

Methods: Twenty-one children and young adults (13 males; mean age, 8.6 ± 5.2 years; range, 1-19 at initial diagnosis) with either newly diagnosed (n = 5) or pretreated (n = 16) CNS tumors were retrospectively analyzed. All patients had previously undergone neuro-oncological work-up including cranial magnetic resonance imaging. In all cases, [F]FET-PET was indicated in a multidisciplinary team conference. The impact of PET imaging on clinical decision-making was assessed. Histopathology (n = 12) and/or clinical and imaging follow-up (n = 9) served as the standard of reference.

Results: The addition of [F]FET-PET to the available information had an impact on further patient management in 14 out of 21 subjects, with avoidance of invasive surgery or biopsy in four patients, biopsy guidance in four patients, change of further treatment in another five patients, and confirmation of diagnosis in one patient.

Conclusion: [F]FET-PET may provide important additional information for treatment guidance in pediatric and adolescent patients with CNS tumors.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119036PMC
http://dx.doi.org/10.1007/s00259-023-06114-6DOI Listing

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