Osseointegration is a fundamental process during which implantable biomaterial integrates with host bone tissue. The surgical procedure of biomaterial implantation is highly associated with the risk of bacterial infection. Thus, the research continues for biodegradable bone void fillers which are able to stimulate the bone tissue regeneration and locally deliver the antibacterial agent. Herein, we obtained bifunctional bioglass (BG) using novel, preoptimized, rapid one-pot synthesis. Following the ISO Standards, the influence of the obtained BG on osteoblast-mediated phenomena, such as osteoconduction and osteoinduction was assessed and compared to two commercial materials: bioactive glass powder 45S and bioactive glass powder 85S. Direct-contact tests revealed osteoblast adhesion to BG particles; whereas, tests on extracts confirmed high viability of cells incubated with BG extract. Analyses of gene expression, alkaline phosphatase activity, and calcium phosphates deposition confirmed the stimulation of early and late stages of osteoblast differentiation and mineralization. Additionally, an extended evaluation of intracellular calcium fluctuations revealed a possible correlation between osteoblast calcium uptake and extracellular matrix mineralization. Moreover, proposed bioglass exhibited satisfactory doxycycline adsorption capacity and release profile. The obtained results confirmed the bifunctionality of the proposed BG and indicated its potential as osseointegrative bone drug delivery system.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijpharm.2023.122610 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
One-pot reaction of 3-vinylchromones, aromatic aldehydes, and ammonium acetate: an efficient approach to highly functionalized 1,6-dihydropyridine derivatives.
RSC Adv
January 2025
Department of Organic Chemistry, Faculty of Chemistry, Alzahra University Vanak Tehran 1993893973 Iran
In this work, we present an efficient strategy for the straightforward synthesis of functionalized 1,6-dihydropyridine derivatives a three-component reaction of 3-vinylchromones, aromatic aldehydes, and ammonium acetate. A tandem procedure including NH aldimine formation/Michael-type addition/opening of the pyrone ring/isomerization/6π-electrocyclization/[1,5]-H shift allows rapid access to a series of dihydropyridines bearing an -hydroxybenzoyl and a benzoyl scaffold in good yields. Readily available precursors, simple heating conditions, and operational simplicity are some highlighted advantages of this transformation.
View Article and Find Full Text PDFPolyurethane-grafted graphene oxide from repurposed foam mattress waste.
RSC Adv
January 2025
Department of Chemistry, Carnegie Mellon University 4400 Fifth Avenue Pittsburgh PA 15213 USA
Polyurethanes (PU) make up a large portion of commodity plastics appearing in applications including insulation, footwear, and memory foam mattresses. Unfortunately, as thermoset polymers, polyurethanes lack a clear path for recycling and repurposing, creating a sustainability issue. Herein, using dynamic depolymerization, we demonstrate a simple one-pot synthesis for preparation of an upcycled polyurethane grafted graphene material (PU-GO).
View Article and Find Full Text PDFFacile preparation, mechanochromic luminescence and excitation wavelength-dependent emission of tetra(1-benzo[]imidazol-2-yl)ethene Zn(II) complexes and their applications.
Dalton Trans
January 2025
Beijing Key Laboratory of Energy Conversion and Storage Materials, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China.
Nowadays, benzimidazole and its derivatives are widely assembled into multifunctional materials with various properties such as mechanochromism, photochromism, thermochromism and electrochromism. Herein, two novel zinc(II) coordination compounds, [Zn(L)Br]·2HO (1) and [Zn(L)Cl]·2HO (2) (L = tetra(1-benzo[]imidazol-2-yl)ethene), have been constructed one-pot facile synthesis from bis(1-benzo[]imidazol-2-yl)methane (L) and zinc(II) salts. The ligand L with a CC double bond was formed by C-C coupling of two sp-C atoms of L in solvothermal synthesis, which provides a new strategy to generate the conjugation system conveniently.
View Article and Find Full Text PDFEfficient Copolymerization of Methyl Methacrylate and Lactide Using Metalate Catalysts.
Macromol Rapid Commun
January 2025
Chimie ParisTech, CNRS, Institut de Recherche de Chimie Paris, PSL University, Paris, 75005, France.
The development of catalysts that are both robust and highly active at room temperature can often be seen as a major challenge in anionic polymerization. However, these properties are desirable for polymer synthesis because they allow for easy and sustainable production of interesting materials. Here, iron and magnesium complexes are used to form in situ generated metalate complexes that are shown to be highly active in the room temperature copolymerization of methyl methacrylate and lactide.
View Article and Find Full Text PDFConstruction and Band Gap-Regulation of Ordered Macro-Microporous Single Crystals of an Amine-Linked Covalent Organic Framework.
ACS Appl Mater Interfaces
January 2025
State Key Laboratory of Bioinspired Interfacial Materials Science, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215123, China.
Heterogeneity engineering provides an effective route to manipulate the chemical and physical properties of covalent organic frameworks (COFs) but is still under development for their single-crystal form. Here, we report the strategy based on a combination of the template-assisted modulated synthesis with a one-pot crystallization-reduction method to directly construct ordered macro-microporous single crystals of an amine-linked three-dimensional (3D) COF (OM-COF-300-SR). In this strategy, the colloidal crystal-templating synthesis not only assists the formation of ordered macropores but also greatly facilitates the in situ conversion of linkages (from imine to amine) in the COF-300 single crystals.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!