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Increased oligodendrogenesis and myelination in the subventricular zone of aged mice and gray mouse lemurs. | LitMetric

Increased oligodendrogenesis and myelination in the subventricular zone of aged mice and gray mouse lemurs.

Stem Cell Reports

Laboratory Molecular Physiology and Adaptation, CNRS UMR 7221, Department Adaptations of Life, Muséum National d'Histoire Naturelle, 7 rue Cuvier, 75005 Paris, France. Electronic address:

Published: February 2023

AI Article Synopsis

  • The subventricular zone (SVZ) in adult rodents produces neural stem cells (NSCs) that migrate to the olfactory bulbs, but their ability to generate oligodendrocyte precursor cells (OPCs) is limited.
  • A study comparing aging effects on neurogliogenesis in mice and gray mouse lemurs found that while NSC neuronal commitment declined with age, OPC generation and myelin content increased unexpectedly in both species.
  • The research identified significant interspecies differences, such as the maturation of OPCs being promoted in mice but blocked in lemurs, suggesting that lemurs might be a more relevant model for studying aging biomarkers.

Article Abstract

The adult rodent subventricular zone (SVZ) generates neural stem cells (NSCs) throughout life that migrate to the olfactory bulbs (OBs) and differentiate into olfactory interneurons. Few SVZ NSCs generate oligodendrocyte precursor cells (OPCs). We investigated how neurogliogenesis is regulated during aging in mice and in a non-human primate (NHP) model, the gray mouse lemur. In both species, neuronal commitment decreased with age, while OPC generation and myelin content unexpectedly increased. In the OBs, more tyrosine hydroxylase interneurons in old mice, but fewer in lemurs, marked a surprising interspecies difference that could relate to our observation of a continuous ventricle in lemurs. In the corpus callosum, aging promoted maturation of OPCs into mature oligodendrocytes in mice but blocked it in lemurs. The present study highlights similarities and dissimilarities between rodents and NHPs, revealing that NHPs are a more relevant model than mice to study the evolution of biomarkers of aging.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969077PMC
http://dx.doi.org/10.1016/j.stemcr.2022.12.015DOI Listing

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