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Hantavirus and Leptospira are important causes of nonspecific acute febrile syndrome, Meta, Colombia.
Travel Med Infect Dis
January 2025
Universidad Cooperativa de Colombia, Facultad de Medicina. Grupo de investigación de Villavicencio-GRIVI, y Centro de Investigación en Salud para el Trópico. Electronic address:
Introduction: Acute undifferentiated febrile illnesses are fevers lasting less than fourteen days without an evident focus of infection on the initial physical examination or with inconclusive laboratory tests.
Objective: Carry out epidemiological surveillance of the etiology of acute undifferentiated febrile syndrome in the Meta department.
Methods: A descriptive, prospective cross-sectional study was carried out between February 2021 and June 2023 in a first-level hospital in the department of Meta, Colombia.
Current antibiotics for leptospirosis: Are still effective?
Heliyon
January 2025
School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Leptospirosis is a recurring zoonotic disease of global significance. Leptospirosis is curable, and antibiotics are available for its treatment. However, little is known about the effectiveness of the currently used antibiotics against different species, serovars, and strains.
View Article and Find Full Text PDFRole of Toll-like receptor 2 during infection of Leptospira spp: A systematic review.
PLoS One
December 2024
International Vaccine Institute, Seoul, Republic of Korea.
Article Synopsis
- The study investigates the role of Toll-like receptor 2 (TLR2) in leptospirosis, a disease not well understood in relation to TLR2 involvement.
- A systematic review was conducted on various studies with 35 articles selected, analyzing TLR2's expression and its association with immune responses during leptospirosis.
- Results showed that while TLR2 was more consistently expressed in experiments, human data yielded mixed findings, indicating a need for more research on TLR2's role in human leptospirosis and its interaction with other receptors like TLR4 and TLR5.
Molecular Evidence of Leptospira spp. Infection Among Household Dogs From 15 Municipalities of the Department of Caldas, Colombia.
Zoonoses Public Health
March 2025
Grupo de Enfermedades Infecciosas, Departamento de Microbiología, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, Colombia.
Introduction: Leptospira spp. is a bacterial genus which includes pathogenic species that causes leptospirosis. Several animal species can harbour, shed and disseminate the bacteria through their urine.
View Article and Find Full Text PDFCellular pathophysiology of Leptospira interrogans infection in canine testicular tissue: role of the TLR4/NF-kB/JNK pathway.
J Comp Pathol
January 2025
Department of Pathology, Faculty of Veterinary Medicine, Atatürk University, 25240 Erzurum, Türkiye.
Leptospirosis is a prevalent zoonotic disease in dogs. Although it is known that leptospires are primarily harboured in kidney tissues of dogs, it has been reported that they also infect testicular tissue. Leptospira interrogans causes various lesions in canine testicular tissues; however, the pathogenesis has not been clearly explained.
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