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In vivo toxic and lethal cardiorespiratory effects of a synthetic quaternary ammonium salt derivative of haloperidol in mice.
Animal Model Exp Med
January 2025
Department of Pharmacology, Shantou University Medical College, Shantou, Guangdong, China.
Background: To investigate the toxicity of N-n-butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes.
Methods: The acute median lethal dose (LD) of F2 was determined using the Bliss method following intravenous administration in mice. Routine surface electrocardiograms (ECGs) and arterial blood pressures (aBPs) were recorded under general anesthesia in untreated and pharmacologically vagotomized mice injected with F2.
Prevalence of Theileria Equi and Babesia Caballi and Associated Hemato-Biochemical Changes in Racing Horses in Erbil Province, Iraq.
Acta Parasitol
January 2025
Department of Biology, College of Sciences, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq.
Purposes: This study aimed to determine the prevalence of Theileria equi (T. equi) and Babesia caballi (B. caballi) in racing horses in Erbil Province, Iraq, and to assess the associated hemato-biochemical changes in infected animals.
View Article and Find Full Text PDFPhytotoxic Effects of Polystyrene Microplastics on Growth Morphology, Photosynthesis, Gaseous Exchange and Oxidative Stress of Wheat Vary with Concentration and Shape.
Toxics
January 2025
Department of Environmental Sciences, Government College University Faisalabad, Faisalabad 38000, Pakistan.
Microplastics pose a serious ecological threat to agricultural soils, as they are very persistent in nature. Microplastics can enter the soil system in different ways and present different shapes and concentrations. However, little is known about how plants react to microplastics with different concentrations and shapes.
View Article and Find Full Text PDFAssessment of Bacterial Community Structure, Associated Functional Role, and Water Health in Full-Scale Municipal Wastewater Treatment Plants.
Toxics
December 2024
Centre for DNA Taxonomy, Molecular Systematics Division, Zoological Survey of India, Kolkata 700053, West Bengal, India.
The present study collected wastewater samples from fourteen (14) full-scale wastewater treatment plants (WWTPs) at different treatment stages, namely, primary, secondary, and tertiary, to understand the impact of WWTP processes on the bacterial community structure, their role, and their correlation with environmental variables (water quality parameters). The findings showed that the bacterial communities in the primary, secondary, and tertiary treatment stages are more or less similar. They are made up of 42 phyla, 84 classes, 154 orders, 212 families, and 268 genera.
View Article and Find Full Text PDFBlack Soldier Fly () Larvae as a Protein Substitute in Adverse Food Reactions for Canine Dermatitis: Preliminary Results Among Patients.
Vet Sci
January 2025
Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand.
Can black soldier fly (BSF) larvae be a protein substitute for managing adverse food reactions (AFRs) in dogs, specifically those with dermatitis? We evaluated BSF larvae's safety, tolerance, and effectiveness as a novel protein source in dogs with AFRs. Sixteen dogs, including eight healthy controls and eight diagnosed with AFRs, were fed a diet containing BSF larvae for four weeks. Skin conditions, including dermatological lesions and Pruritus Visual Analog Scale (PVAS) scores, and gastrointestinal signs, including relevant clinical signs, stool consistency, and hematological and biochemical parameters, were monitored.
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