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The Effects of Circadian Rhythm on Lead-Induced Toxicity in the DBC1.2 Olfactory Dark Basal Cell Line.
Cells
January 2025
Department of Otolaryngology, Tokyo Teishin Hospital, Tokyo 102-0071, Japan.
Background/objectives: This study evaluated changes in circadian clock genes and mitochondrial function in a lead (Pb)-induced toxicity model of an olfactory epithelial cell line.
Methods: The DBC1.2 olfactory dark basal cell line was used.
Emergent robust oscillatory dynamics in the interlocked feedback-feedforward loops.
IET Syst Biol
January 2025
Center for Computational Biology, Department of Computational Biology, IIIT-Delhi, New Delhi, India.
One of the challenges that beset modelling complex biological networks is to relate networks to function to dynamics. A further challenge is deciphering the cellular function and dynamics that can change drastically when the network edge is tinkered with by adding or removing it. To illustrate this, the authors took a well-studied three-variable Goodwin oscillatory motif with only a negative feedback loop.
View Article and Find Full Text PDFRelationship between platelet distribution width and non-dipping pattern in children with essential hypertension.
BMC Pediatr
January 2025
Department of Cardiology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Background: Hypertension has shown a trend of prevalence at younger ages, and the non-dipping pattern is associated with target organ damage in hypertension. However, few studies have yet investigated the clinical characteristics and risk factors of non-dipper status in essential hypertension children. This study aimed to explore the clinical characteristics and possible indicators associated with non-dipper status in children with essential hypertension.
View Article and Find Full Text PDFChronic restraint stress affects the diurnal rhythms of gut microbial composition and metabolism in a mouse model of depression.
BMC Microbiol
January 2025
Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
Background: Depression is a common mental disorder accompanied by gut microbiota dysbiosis, which disturbs the metabolism of the host. While diurnal oscillation of the intestinal microbiota is involved in regulating host metabolism, the characteristics of the intestinal microbial circadian rhythm in depression remain unknown. Our aim was to investigate the microbial circadian oscillation signature and related metabolic pathways in a mouse model with depression-like behaviours.
View Article and Find Full Text PDFThe gut microbiota predicts and time-restricted feeding delays experimental colitis.
Gut Microbes
December 2025
Department of Microbiome Research and Applied Bioinformatics, Institute for Nutritional Sciences, University of Hohenheim, Stuttgart, Germany.
The etiology of inflammatory bowel disease (IBD) remains unclear, treatment options unsatisfactory and disease development difficult to predict for individual patients. Dysbiosis of the gastrointestinal microbiota and disruption of the biological clock have been implicated and studied as diagnostic and therapeutic targets. Here, we examine the relationship of IBD to biological clock and gut microbiota by using the IL-10 deficient () mouse model for microbiota-dependent spontaneous colitis in combination with altered (4 h/4 h) light/dark cycles to disrupt and time-restricted feeding (TRF) to restore circadian rhythmicity.
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