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Diagnostic outcomes after gluten challenge in adult patients with unconfirmed coeliac disease already on a gluten-free diet: A 20-year retrospective cohort study.
Dig Liver Dis
January 2025
Department of Internal Medicine and Therapeutics, University of Pavia, Italy; Istituti Clinici Scientifici Maugeri IRCCS, Gastroenterology Unit of Pavia Institute, Italy.
Background: In uncertain cases of coeliac disease (CD), gluten challenge (GC) may be necessary to confirm or exclude the diagnosis. However, data on diagnostic outcomes after GC are limited.
Aims: We aimed to evaluate outcomes after GC in patients with unconfirmed CD who had already started a gluten-free diet (GFD), and identify predictors of a confirmed diagnosis.
Celiac disease, non-celiac wheat sensitivity, wheat allergy - clinical and diagnostic aspects.
Semin Immunol
January 2025
Celiac Disease Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Tampere Centre for Child, Adolescent and Maternal Health Research, Tampere University and Tampere University Hospital, Tampere, Finland; The Wellbeing Services County of Pirkanmaa, Finland; The University Consortium of Seinäjoki, Seinäjoki, Finland. Electronic address:
In recent years, wheat- and gluten-free diets have increased in demand due to reported increases in various conditions reported to be driven by ingredients of these food products. Celiac disease, wheat allergy and non-celiac wheat sensitivity constitute the three main categories of wheat-related disorders. Celiac disease is a well-characterized immune-mediated disease caused by immune reaction against specific gliadin epitopes, the main protein in wheat.
View Article and Find Full Text PDFFood protein-induced enterocolitis syndrome after involuntary gluten transgression in celiac children: A new increasingly common complication?
Nutrition
November 2024
UGC Pediatrics, Hospital de la Axarquía, Vélez-Málaga, Málaga, Spain.
Among the possible adverse reactions to gluten, celiac disease, non-celiac gluten sensitivity, and IgE-mediated wheat allergy have been classically described. A non-IgE-mediated reaction similar to food protein-induced enterocolitis syndrome (FPIES) after inadvertent gluten ingestion in a celiac patient was recently reported. We present three children affected by celiac disease with exquisite control, including appropriate adherence to an exclusion diet, who suffered a severe adverse food reaction after unappreciated outdoor ingestion of gluten, meeting the criteria for a definitive diagnosis of FPIES.
View Article and Find Full Text PDFSerum metabolomics and lipoproteomics discriminate celiac disease and non-celiac gluten sensitivity patients.
Clin Nutr
December 2024
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy. Electronic address:
Background&aims: Celiac disease (CD) and potential CD (pCD) are immune-mediated disorders triggered by the ingestion of gluten. In non-celiac gluten sensitivity (NCGS) neither allergic nor autoimmune mechanisms are involved. Relationships between NCGS and CD need to be further investigated.
View Article and Find Full Text PDFOptimization of Functional Gluten-Free Cake Formulation Using Rice Flour, Coconut Flour, and Xanthan Gum via D-Optimal Mixture Design.
Food Sci Nutr
December 2024
Department of Food Science and Technology, Science and Research Branch Islamic Azad University Tehran Iran.
Article Synopsis
- Prolamins found in wheat, barley, and rye are linked to health issues like celiac disease and wheat allergies, pushing the need for gluten-free alternatives like rice flour, though its products are not as high-tech.
- Adding low-fat desiccated coconut flour and xanthan gum to rice flour significantly improves the quality and properties of gluten-free cakes, impacting viscosity, moisture, and texture.
- The study successfully optimized a gluten-free cake recipe, achieving improved sensory qualities (taste, texture, etc.) through careful ratios of rice flour, coconut flour, and xanthan gum, validated by strong statistical models.
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