Fucoidan is a sulfated algal polyanionic polysaccharide that possesses many biological activities. In this paper, a fucoidan (SHF) polysaccharide was extracted from collected in the South China Sea. The SHF, with a molecular weight of 1166.48 kDa (44.06%, /), consisted of glucose (32.68%, /), galactose (24.81%, /), fucose (20.75%, /), xylose (6.98%, /), mannose (2.76%, /), other neutral monosaccharides, and three uronic acids, including glucuronic acid (5.39%, /), mannuronic acid (1.76%, /), and guronuronic acid (1.76%, /). The SHF exhibited excellent immunostimulatory activity. An immunostimulating assay showed that SHF could significantly increase NO secretion in macrophage RAW 264.7 cells via upregulation of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) levels based on both gene expression and protein abundance. These results suggest that SHF isolated from has great potential to act as a health-boosting ingredient in the pharmaceutical and functional-food fields.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865083 | PMC |
| http://dx.doi.org/10.3390/md21010018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Based on theoretical design simultaneous analysis of multiple neonicotinoid pesticides in beeswax by deep eutectic solvents extraction combined with UHPLC-MS/MS.
Food Chem X
January 2025
State Key Laboratory of Resource Insects, Institute of Apiculture Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China.
Beeswax, an FDA-approved component, has been extensively applied in feed, pharmaceutical, and food industries. The occurrence of neonicotinoid pesticides in beehive systems and their residues in beeswax have caused safety risks. Therefore, establishing a detection method for neonicotinoid pesticide residues in beeswax is crucial for ensuring its quality.
View Article and Find Full Text PDFExploring the causal impact of body mass index on metabolic biomarkers and cholelithiasis risk: a Mendelian randomization analysis.
Sci Rep
January 2025
The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, Gansu Province, China.
Article Synopsis
- Obesity is a significant risk factor for diseases, but it's still unclear how it contributes to disease development, prompting a study using Mendelian randomization to analyze the relationship between BMI, metabolic traits, and cholelithiasis.
- BMI was found to positively affect the risk of developing cholelithiasis across multiple datasets, with 176 metabolites linked to BMI identified, including crucial fats and cholesterol types.
- The study highlights key metabolites that mediate the BMI-cholelithiasis connection, emphasizing the need for effective BMI management to reduce metabolic dysfunction and gallstone risk, while calling for further research into the underlying metabolic pathways.
Characteristics of patients with non-severe infections of different SARS-CoV-2 omicron subvariants in China.
Front Med (Lausanne)
December 2024
Hebei Key Laboratory of Immune Mechanism of Major Infectious Diseases and New Technology of Diagnosis and Treatment, The Fifth Hospital of Shijiazhuang, Shijiazhuang, Hebei, China.
Objective: The aim of this study was to explore the clinical characteristics of patients infected with different Omicron subvariants presenting non-severe disease, evaluate the safety and efficacy of Azvudine for treatment of COVID-19, in order to broaden understanding of Omicron subvariant infections.
Method: A total of 244 individuals with Omicron subvariant (BA.2.
The molecular epidemiology of respiratory syncytial virus in Ontario, Canada from 2022-2024 using a custom whole genome sequencing assay and analytics package.
J Clin Virol
December 2024
Division of Microbiology, Kingston Health Sciences Centre, Kingston, ON, Canada; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada; Infectious Disease Sequencing Laboratory, Kingston Health Sciences Centre, Kingston, ON, Canada; Gastrointestinal Disease Research Unit, Department of Medicine, Queen's University, Kingston, ON, Canada.
Background: Respiratory Syncytial Virus (RSV) infections are a cause of significant morbidity and mortality in children and the elderly. Despite the clinical burden of disease, very little is known about the inter- and intra-seasonal genomic variability of RSV. Furthermore, the recent approval of vaccines and monoclonal antibody therapies will likely lead to higher selective pressure on RSV.
View Article and Find Full Text PDFSignal transducer of IAA related gene expression induces transporters of hyperaccumulator for Pb accumulation.
Int J Phytoremediation
December 2024
College of Resources and Environment, Yunnan Agricultural University, Kunming, P.R. China.
Lead (Pb) pollution in soil affects growth of plants. Plants' endogenous hormones play an important role in resistance to Pb of plant. In order to explore the hormone-based mechanisms of Pb accumulationin in hyperaccumulator , a pot experiment was conducted to analyze the contents of endogenous hormones (auxin, gibberellin, abscisic acid, and cytokinin) and related genes expressions, and Pb contents of , as well as the transporter (cation exchangers (CAX), heavy metal ATPases (HMA), and ATP-binding cassette (ABC)) concentrations under foliar spraying of indoleacetic acid (IAA).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!