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Flexible Polymer Electrodes for Stable Prosthetic Visual Perception in Mice.
Adv Healthc Mater
June 2024
Department of Vision and Cognition, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, 1105 BA, The Netherlands.
Brain interfaces that can stimulate neurons, cause minimal damage, and work for a long time will be central for future neuroprosthetics. Here, the long-term performance of highly flexible, thin polyimide shanks with several small (<15 µm) electrodes during electrical microstimulation of the visual cortex, is reported. The electrodes exhibit a remarkable stability when several billions of electrical pulses are applied in vitro.
View Article and Find Full Text PDFAn organ-on-chip device with integrated charge sensors and recording microelectrodes.
Sci Rep
May 2023
ECTM, Department of Microelectronics, Delft University of Technology, Delft, 2628 CD, The Netherlands.
Continuous monitoring of tissue microphysiology is a key enabling feature of the organ-on-chip (OoC) approach for in vitro drug screening and disease modeling. Integrated sensing units are particularly convenient for microenvironmental monitoring. However, sensitive in vitro and real-time measurements are challenging due to the inherently small size of OoC devices, the characteristics of commonly used materials, and external hardware setups required to support the sensing units.
View Article and Find Full Text PDFIn-vivo testing of a novel wireless intraspinal microstimulation interface for restoration of motor function following spinal cord injury.
Artif Organs
March 2024
Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, USA.
Background: Spinal cord injury causes a drastic loss in motor and sensory function. Intraspinal microstimulation (ISMS) is an electrical stimulation method developed for restoring motor function by activating the spinal networks below the level of injury. Current ISMS technology uses fine penetrating microwires to stimulate the ventral horn of the lumbar enlargement.
View Article and Find Full Text PDFStretchable mesh microelectronics for the biointegration and stimulation of human neural organoids.
Biomaterials
November 2022
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA; Stanford Brain Organogenesis, Wu Tsai Neuroscience Institute, Stanford, CA, 94305, USA. Electronic address:
Advances in tridimensional (3D) culture approaches have led to the generation of organoids that recapitulate cellular and physiological features of domains of the human nervous system. Although microelectrodes have been developed for long-term electrophysiological interfaces with neural tissue, studies of long-term interfaces between microelectrodes and free-floating organoids remain limited. In this study, we report a stretchable, soft mesh electrode system that establishes an intimate in vitro electrical interface with human neurons in 3D organoids.
View Article and Find Full Text PDFThin flexible arrays for long-term multi-electrode recordings in macaque primary visual cortex.
J Neural Eng
December 2022
Laboratory for Neuro- and Psychophysiology, KU Leuven, Leuven 3000, Belgium.
Basic, translational and clinical neuroscience are increasingly focusing on large-scale invasive recordings of neuronal activity. However, in large animals such as nonhuman primates and humans-in which the larger brain size with sulci and gyri imposes additional challenges compared to rodents, there is a huge unmet need to record from hundreds of neurons simultaneously anywhere in the brain for long periods of time. Here, we tested the electrical and mechanical properties of thin, flexible multi-electrode arrays (MEAs) inserted into the primary visual cortex of two macaque monkeys, and assessed their magnetic resonance imaging (MRI) compatibility and their capacity to record extracellular activity over a period of 1 year.
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