The growth of digital libraries has yielded a large number of handwritten historical documents in the form of images, often accompanied by a digital transcription of the content. The ability to track the position of the words of the digital transcription in the images can be important both for the study of the document by humanities scholars and for further automatic processing. We propose a learning-free method for automatically aligning the transcription to the document image. The method receives as input the digital image of the document and the transcription of its content and aims at linking the transcription to the corresponding images within the page at the word level. The method comprises two main original contributions: a line-level segmentation algorithm capable of detecting text lines with curved baseline, and a text-to-image alignment algorithm capable of dealing with under- and over-segmentation errors at the word level. Experiments on pages from a 17th-century Italian manuscript have demonstrated that the line segmentation method allows one to segment 92% of the text line correctly. They also demonstrated that it achieves a correct alignment accuracy greater than 68%. Moreover, the performance achieved on widely used data sets compare favourably with the state of the art.
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http://dx.doi.org/10.3390/jimaging9010017 | DOI Listing |
Front Psychol
January 2025
Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States.
Introduction: Public discussions in the media (e.g., social media and reality shows) about Black women's mental health have become more common.
View Article and Find Full Text PDFMol Neurodegener
January 2025
Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA.
Alzheimer's disease (AD) is a debilitating neurodegenerative disease that is marked by profound neurovascular dysfunction and significant cell-specific alterations in the brain vasculature. Recent advances in high throughput single-cell transcriptomics technology have enabled the study of the human brain vasculature at an unprecedented depth. Additionally, the understudied niche of cerebrovascular cells, such as endothelial and mural cells, and their subtypes have been scrutinized for understanding cellular and transcriptional heterogeneity in AD.
View Article and Find Full Text PDFFront Oral Health
January 2025
Doctoral School of Health Sciences, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary.
Background: In recent years, dental clusters and networks have been established in primary care in many countries to improve access to services for the population and develop cooperation between providers. In Hungary, the first dental clusters were established in 2021, and currently, one-third of dental practices have already joined a cluster. The study aimed to gather and analyze early experiences regarding the motivation of participation in primary care dental clusters and experiences of implementation.
View Article and Find Full Text PDFJ Immunother Cancer
January 2025
Cancer Gene Therapy Group, Translational Immunology Research Program, University of Helsinki, Helsinki, Finland
Background: Oncolytic viruses (OVs) are promising immunotherapeutics to treat immunologically cold tumors. However, research on the mechanism of action of OVs in humans and clinically relevant biomarkers is still sparse. To induce strong T-cell responses against solid tumors, TILT-123 (Ad5/3-E2F-d24-hTNFa-IRES-hIL2, igrelimogene litadenorepvec) was developed.
View Article and Find Full Text PDFbioRxiv
January 2025
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Amylin analogs, including potential anti-obesity therapies like cagrilintide, act on neurons in the brainstem dorsal vagal complex (DVC) that express calcitonin receptors (CALCR). These receptors, often combined with receptor activity-modifying proteins (RAMPs), mediate the suppression of food intake and body weight. To understand the molecular and neural mechanisms of cagrilintide action, we used single-nucleus RNA sequencing to define 89 cell populations across the rat, mouse, and non-human primate caudal brainstem.
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