The global covid-19 pandemic has imposed radical changes in daily lives. This study reflects upon sociodemographic and clinical characteristics (sleep-wake rhythm, psychiatric symptoms, and alcohol use behavior) during the full lockdown, comparing individuals who increased their alcohol use (iAU), those who maintained a stable use (sAU), and those who did not consume alcohol (AnoU). Participants were recruited via e-mails and they were required to complete an online survey that included questionnaires, during the last week of the full lockdown. The iAU group, compared to the sAU group, presented more disturbed sleep (PSQI; < .001), more severe insomnia (ISI; < .001), shorter sleep duration ( < .001), longer sleep latency ( < .001), and less regular sleep-wake schedules ( = .005). They also reported more anxiety (HAD-A; = .009), more depressive symptoms (HAD-D: = .006) and more psychotraumatic symptoms (PCL-5: = .018). Moreover, the sAU group, compared to AnoU, showed better quality of sleep (PSQI; = .002) and less severe anxiety symptoms (HAD-A; = .014). Maintaining a stable use was also related to a better quality of life associated with bigger homes with more frequent outdoors living spaces and higher monthly incomes. Individuals who increased their alcohol consumption during the Covid-19 lockdown exhibited more sleep and circadian rhythm disturbances, as well as more (severe) psychiatric symptoms.
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http://dx.doi.org/10.1080/07420528.2023.2168199 | DOI Listing |
Alzheimers Dement
December 2024
Columbia University, New York, NY, USA.
Background: As high as 50% of Alzheimer's disease (AD) patients experience "sundowning", which refers to an increased severity of neuropsychiatric symptoms (NPS), including agitation, confusion, and anxiety, selectively in the evening. Although sundowning significantly influences the decision to institutionalize patients, few preclinical models of this phenomenon exist and the underlying neural mechanisms are unknown. Here, we establish a model of sundowning by phenotyping the sleep-wake cycle and anxiety and exploratory behavior at different times of day in an AD mouse model.
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December 2024
University of Kentucky, Lexington, KY, USA.
Background: Alzheimer's disease is defined by the pathological aggregation of amyloid-beta and hyperphosphorylated tau. AD patients often exhibit other symptoms like metabolic and sleep dysfunction. Currently, it is unclear if impairments are a cause or consequence of Aβ or tau aggregation.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands, Maastricht, Netherlands; Gordon Center for Medical Imaging, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Background: The brainstem locus coeruleus (LC) is among the first sites of Alzheimer's disease (AD) pathology, accruing hyperphosphorylated tau as early as in young adulthood. Animal studies indicate that the LC is crucially involved in sleep-wake regulation, a recently established factor contributing to AD-related pathophysiological processes. However, the associations between LC integrity and sleep-wake phenotypes in the context of AD pathology remain poorly characterized in humans.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Bristol, Bristol, United Kingdom.
Background: Homeostatic sleep regulation is theorized to be governed by the 'Two Process Model' where circadian rhythm (process C) and homeostatic sleep pressure (process S) interact to determine sleep versus wakefulness. Sleep pressure accumulated during prolonged wakefulness increases the duration and intensity of subsequent 'recovery' sleep. Multiple sleep abnormalities are associated with Alzheimer's Disease (AD) Dementia and Lewy Body Dementia (LBD).
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January 2025
Institute for Electric Light Sources, School of Information Science and Technology, Fudan University, Shanghai, 200438, China.
Sleep disorders constitute a significant disruption for shift workers. Beyond medical interventions, phototherapy is recognized as an effective approach to significantly alleviate sleep disorders, particularly among individuals engaged in shift work. However, the effective dose and efficacy evaluation of phototherapy have not yet been determined.
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