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Osteocyte Dendrites: How Do They Grow, Mature, and Degenerate in Mineralized Bone?
Cytoskeleton (Hoboken)
December 2024
Department of Biomedical Engineering, University of Delaware, Newark, Delaware, USA.
Osteocytes, the most abundant bone cells, form an extensive cellular network via interconnecting dendrites. Like neurons in the brain, the long-lived osteocytes perceive mechanical and biological inputs and signal to other effector cells, leading to the homeostasis and turnover of bone tissues. Despite the appreciation of osteocytes' vital roles in bone biology, the initiation, growth, maintenance, and eventual degradation of osteocyte dendrites are poorly understood due to their full encasement by mineralized matrix.
View Article and Find Full Text PDFSimilarities and differences in the gene expression signatures of physiological age versus future lifespan.
Aging Cell
December 2024
Department of Developmental Biology, Washington University in St. Louis, St. Louis, Missouri, USA.
Article Synopsis
- Lifespan variability exists within species, including genetically identical Caenorhabditis elegans, indicating factors beyond genotype and environment influence longevity.
- Researchers identified biomarkers that strongly predict lifespan, some being positively correlated (lin-4p::GFP, mir-243p::GFP) and others negatively correlated (mir-240/786p::GFP, autofluorescence), suggesting a shared health state linked to longevity.
- The study revealed that even among individuals of the same chronological age, those predicted to be long- or short-lived had notable differences in their gene expression profiles, indicating that lifespan predictions involve more than just typical aging processes.
Electron-Spin Relaxation in Boron-Doped Graphene Nanoribbons.
J Chem Theory Comput
November 2024
Donostia International Physics Center DIPC, Paseo Manuel Lardizabal 4, 20018 Donostia-San Sebastián, Spain.
Boron-doped graphene nanoribbons are promising platforms for developing organic materials with magnetic properties. Boron dopants can be used to create localized magnetic states in nanoribbons with tunable interactions. Controlling the coherence times of these magnetic states is the very first step in designing materials for quantum computation or information storage.
View Article and Find Full Text PDFRigid and planar π-conjugated molecules leading to long-lived intramolecular charge-transfer states exhibiting thermally activated delayed fluorescence.
Nat Commun
November 2024
Department of Physics, Durham University, South Road, Durham, DH1 3LE, UK.
Intramolecular charge transfer (ICT) occurs when photoexcitation causes electron transfer from an electron donor to an electron acceptor within the same molecule and is usually stabilized by decoupling of the donor and acceptor through an orthogonal twist between them. Thermally activated delayed fluorescence (TADF) exploits such twisted ICT states to harvest triplet excitons in OLEDs. However, the highly twisted conformation of TADF molecules results in limited device lifetimes.
View Article and Find Full Text PDFMetrics of Physiological Network Topology Are Novel Biomarkers to Capture Functional Disability and Health.
J Gerontol A Biol Sci Med Sci
December 2024
Department of Geriatrics, Huadong Hospital, Shanghai Medical College, Fudan University, Human Phenome Institute, Fudan University, Shanghai, China.
Background: Physiological networks are highly complex, integrating connections among multiple organ systems and their dynamic changes underlying human aging. It is unknown whether individual-level network could serve as robust biomarkers for health and aging.
Methods: We used personalized network analysis to construct a single-sample network and examine the associations between network properties and functional disability in the Rugao Longevity and Aging Study (RuLAS), the China Health and Retirement Longitudinal Study (CHARLS), the Chinese Longitudinal Healthy Longevity Survey (CLHLS), and the National Health and Nutrition Examination Survey (NHANES).
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