It has been proposed that nitrilotriacetic acid be substituted for trisodium polyphosphates in detergents as a way to reduce the rate of eutrophication in the Great Lake Basin. The reaction of nitrilotriacetic acid with chlorine-containing solutions produces a hitherto unknown degradation production, N-formyliminodiacetic acid, in high yield. The toxicological and environmental implications of this reaction are unclear.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1126/science.36659 | DOI Listing |
Cell Biol Toxicol
January 2025
Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Alzheimer's disease (AD), the most prevalent form of dementia in the elderly, involves critical changes such as reduced aerobic glycolysis in astrocytes and increased neuronal apoptosis, both of which are significant in the disease's pathology. In our study, astrocytes treated with amyloid β1-42 (Aβ) to simulate AD conditions exhibited upregulated expressions of small ubiquitin-like modifier (SUMO)-specific protease 1 (SENP1) and Pumilio RNA Binding Family Member 2 (PUM2), alongside decreased levels of Nuclear factor erythroid 2-related factor 2 (NRF2). SENP1 is notably the most upregulated SUMOylation enzyme in Aβ-exposed astrocytes.
View Article and Find Full Text PDFPorcine circovirus type 2 (PCV2) is the major causative agent of postweaning multisystemic wasting syndrome which leads to significant economic losses in the global swine industry. In China, there is a widespread dissemination of PCV2 infection in the pig population. Serological diagnosis of the disease is considered as an effective control measure.
View Article and Find Full Text PDFArch Biochem Biophys
February 2025
Medical Proteomics Unit, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand. Electronic address:
Annexin A2 (ANXA2) is a Ca-dependent multifunctional protein containing five Ca-binding domains, but their functional significance and difference remain unclear. Herein, glutamic acid (E) or aspartic acid (D) in five Ca-binding domains of canine ANXA2 (98.82 % and 96.
View Article and Find Full Text PDFJ Virol Methods
December 2024
Department of Biosciences and Bioengineering, Indian Institute of Technology, Roorkee, Uttarakhand, India. Electronic address:
Current research efforts are underway to create novel approaches for the efficient diagnosis, monitoring, and mitigation of Kyasanur Forest Disease Virus (KFDV) infections. Flavivirus subunit-based vaccines based on envelope glycoprotein EDIII are now in preclinical and clinical research stages. Efficient purification and isolation methods for surface immunogenic viral antigens, including the recombinant envelope immunoglobulin-like domain III (rEDIII) protein, are crucial for the production and manufacturing of promising vaccine candidates that have been extensively assessed in previous literature.
View Article and Find Full Text PDFNanoscale Adv
December 2024
Department of Inorganic and Physical Chemistry, IISc Bangalore India
Enormous amounts of toxic synthetic dyes and inorganic contaminants, such as heavy metals, are regularly discharged into local water bodies unregulated and untreated through effluents from a wide range of industries. Designing industrial methodologies that limit or eliminate the unloading of harmful substances in the surrounding environment has become a requisite for sustainable growth. Although the magnetic separation-based adsorption technique seems quite promising, the functional moieties on the nanoparticle surface often restrict the choice of target pollutants, limiting their universal applicability.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!