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Linking higher amyloid beta 1-38 (Aβ(1-38)) levels to reduced Alzheimer's disease progression risk.
Alzheimers Dement
January 2025
Department of Psychiatry and Neuroscience, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Introduction: The beneficial effects of amyloid beta 1-38, or Aβ(1-38), on Alzheimer's disease (AD) progression in humans in vivo remain controversial. We investigated AD patients' cerebrospinal fluid (CSF) Aβ(1-38) and AD progression.
Methods: Cognitive function and diagnostic change were assessed annually for 3 years in 177 Aβ-positive participants with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and dementia from the German Center for Neurodegenerative Diseases (DZNE) longitudinal cognitive impairment and dementia study (DELCODE) cohort using the Mini-Mental State Examination (MMSE), Preclinical Alzheimer's Cognitive Composite (PACC), Clinical Dementia Rating (CDR), and National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria.
Background And Aims: This article explores antibiotic resistance as a critical public health issue in Bangladesh, emphasizing its growing threat to the nation's healthcare system. As a developing country, Bangladesh faces unique challenges in managing this crisis, with antibiotic resistance posing significant risks due to its multidimensional problems to both individual health and the broader population.
Methods: We searched for relevant pieces of literature that discuss the antibiotic resistance problem both from a global and national perspective.
Healthcare provision for displaced people in transit: Analyses of routinely collected data from INTERSOS clinics at the Ukrainian border with Moldova and Poland.
J Migr Health
December 2024
INTERSOS HELLAS, Thessaloniki, Greece.
Background: The Russian military invasion of Ukraine has sparked Europe's largest forced displacement since World War II, bringing about significant health vulnerabilities for migrants and refugees. European health information systems lack comprehensive data coverage, especially in underrepresented migration stages like transit. This study aims to address this gap by analyzing data from INTERSOS clinics at the Moldovan and Polish borders with Ukraine to identify the common health conditions prompting people to seek healthcare services during transit.
View Article and Find Full Text PDFHeat Stroke in the Era of Global Warming: A Call for Urgent Action.
Ann Glob Health
January 2025
Dow University of Health Sciences, Karachi, Pakistan.
Heat stroke (HS) represents a life‑endangering condition that is due to an imbalance between heat generation and dissipation, owing to exposure to hot environments or strenuous exercise. HS is a medical condition that is gaining increased prevalence throughout the world due to a steady rise in temperature, and massive mortalities have been recorded among vulnerable populations. In 2024, extreme heat waves led to increased cases of HS and related fatalities globally, particularly in Karachi, Pakistan.
View Article and Find Full Text PDFFluorescent Particles Based on Aggregation-Induced Emission for Optical Diagnostics of the Central Nervous System.
Research (Wash D C)
January 2025
Biomedical Engineering, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.
In 2001, Tang's team discovered a unique type of luminogens with substantial enhanced fluorescence upon aggregation and introduced the concept of "aggregation-induced emission (AIE)". Unlike conventional fluorescent materials, AIE luminogens (AIEgens) emit weak or no fluorescence in solution but become highly fluorescent in aggregated or solid states, due to a mechanism known as restriction of intramolecular motions (RIM). Initially considered a purely inorganic chemical phenomenon, AIE was later applied in biomedicine to improve the sensitivity of immunoassays.
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