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An actin starry night regulates seed size.
Nat Plants
February 2023
IJPB, INRAE, Versailles, France.
Melanin Distribution in Human Skin: Influence of Cytoskeletal, Polarity, and Centrosome-Related Machinery of Keratinocytes.
Int J Mol Sci
March 2021
The Charles Institute of Dermatology, School of Medicine, University College Dublin, D04 V1W8 Dublin, Ireland.
Melanin granules cluster within supra-nuclear caps in basal keratinocytes (KCs) of the human epidermis, where they protect KC genomic DNA against ultraviolet radiation (UVR) damage. While much is known about melanogenesis in melanocytes (MCs) and a moderate amount about melanin transfer from MC to KC, we know little about the fate of melanin once inside KCs. We recently reported that melanin fate in progenitor KCs is regulated by rare asymmetric organelle movement during mitosis.
View Article and Find Full Text PDFA cytoskeletal activator and inhibitor are downstream targets of the frizzled/starry night planar cell polarity pathway in the Drosophila epidermis.
Prog Biophys Mol Biol
September 2018
Biology Department and Cell Biology Department, University of Virginia, Charlottesville, VA 22904, USA. Electronic address:
The frizzled pathway regulates the planar polarity of epithelial cells. In insects this is manifested by the polarity of cuticular structures such as hairs (trichomes) and sensory bristles. A variety of evidence has established that this is achieved by regulating the subcellular location for activating the cytoskeleton in the epithelial cells.
View Article and Find Full Text PDFThe Drosophila planar polarity gene multiple wing hairs directly regulates the actin cytoskeleton.
Development
July 2015
Departments of Biology and Cell Biology, University of Virginia, Charlottesville, VA 22904, USA
The evolutionarily conserved frizzled/starry night (fz/stan) pathway regulates planar cell polarity (PCP) in vertebrates and invertebrates. This pathway has been extensively studied in the Drosophila wing, where it is manifested by an array of distally pointing cuticular hairs. Using in vivo imaging we found that, early in hair growth, cells have multiple actin bundles and hairs that subsequently fuse into a single growing hair.
View Article and Find Full Text PDFThe diaphanous gene of Drosophila interacts antagonistically with multiple wing hairs and plays a key role in wing hair morphogenesis.
PLoS One
January 2016
Biology Department, University of Virginia, Charlottesville, Virginia, United States of America; Cell Biology Department, University of Virginia, Charlottesville, Virginia, United States of America.
The Drosophila wing is covered by an array of distally pointing hairs that has served as a key model system for studying planar cell polarity (PCP). The adult cuticular hairs are formed in the pupae from cell extensions that contain extensive actin filaments and microtubules. The importance of the actin cytoskeleton for hair growth and morphogenesis is clear from the wide range of phenotypes seen in mutations in well-known actin regulators.
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