AI Article Synopsis
- Lymph node metastasis is a serious concern in cervical cancer patients, and understanding its mechanisms could improve treatment strategies.
- Research highlights the significance of circular RNA circVPRBP, which shows a connection to lymph node metastasis and survival outcomes.
- Overexpressing circVPRBP slows down lymphangiogenesis and metastasis, while silencing it has the opposite effect; circVPRBP aids RACK1 degradation to inhibit cancer metastasis.
Article Abstract
Lymph node (LN) metastasis is one of the most malignant clinical features in patients with cervical cancer (CCa). Understanding the mechanism of lymph node metastasis will provide treatment strategies for patients with CCa. Circular RNAs (circRNA) play a critical role in the development of human cancers. However, the role and mechanism of circRNAs in lymph node metastasis remain largely unknown. Here, it is reported that loss expression of circRNA circVPRBP was closely associated with LN metastasis and poor survival of CCa patients. In vitro and in vivo assays showed that circVPRBP overexpression notably inhibited lymphangiogenesis and LN metastasis, whereas RfxCas13d mediated silencing of circVPRBP promoted lymphangiogenesis and the ability of the cervical cancer cells to metastasize to the LNs. Mechanistically, circVPRBP could bind to RACK1 and shield the S122 O-GlcNAcylation site to promote RACK1 degradation, resulting in inhibition of Galectin-1 mediated lymphangiogenesis and LN metastasis in CCa. Taken together, the results demonstrate that circVPRBP is a potential prognostic biomarker and a novel therapeutic target for LN metastasis in CCa patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005957 | PMC |
| http://dx.doi.org/10.1038/s41388-023-02595-9 | DOI Listing |
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