Cyclobutrifluram is a novel succinate dehydrogenase inhibitor (SDHI) developed by Syngenta and helps to inhibit . Here, the potential for cyclobutrifluram resistance in and the resistance mechanism involved were evaluated. Baseline sensitivity of to cyclobutrifluram was determined with a mean EC value of 0.0248 μg/mL. Fungicide adaption generated five resistant mutants, which possess a comparable or a slightly impaired fitness compared to corresponding parental isolates. This indicates that the resistance risk of to cyclobutrifluram might be moderate. Cyclobutrifluram-resistant isolates also demonstrated resistance to pydiflumetofen but sensitivity to carbendazim, phenamacril, tebuconazole, fludioxonil, or pyraclostrobin. Additionally, point mutations H248Y in FpSdhB and A83V or R86K in FpSdhC were found in cyclobutrifluram-resistant mutants. Molecular docking and overexpression transformation assay revealed that FpSdhB and FpSdhC or FpSdhC confer the resistance of to cyclobutrifluram.
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