Relationship between failure strain, molecular weight, and chain extensibility in biodegradable polymers.

Prior to degradation, biocompatible polymers exhibit ductile behaviour and yield stress offers a suitable design approach. However, as degradation proceeds the material transitions to a brittle failure mode, suggesting a more conservative design approach is necessary. Here, we predict the evolving ductility of biodegrading polymers, concentrating on the relationship between molecular weight and failure strain, ε, in poly (lactic acid). Several datasets are chosen from literature to explore the relationship, with an overview of the experimental techniques provided. Failure criteria are proposed and examined alongside these datasets: the first assumes ε is related to the finite chain extensibility of an average chain; the second introduces an exponential empirical trend; the third proposes a modified extensibility criterion (based on the first criterion) that considers the entire molecular weight distribution; and the fourth offers an alternative to the third by considering the effect of chain scissions. Combining the failure criteria with a previously introduced time-dependent kinetic scission model provides results as a function of degradation duration. The predictions obtained can offer insight into material failure, particularly at advanced stages of degradation.