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Background And Objective: Previously, the novel small molecule ISFP10 has been shown to inhibit fungal phosphoglucomutase (PGM) activity in and spp. With 50-fold selectivity over the human PGM molecule due to the presence of a unique yet conserved cysteine residue present in a number pathogenic fungal PGMs, use of this compound may provide a novel broad-spectrum approach to treating fungal infections. Accordingly, we sought to determine the tolerability in test animals receiving this compound, as well as the potential antifungal activity of ISFP10 on cultures of the common fungal pathogens and .
View Article and Find Full Text PDFThe effect of different root canal irrigations on the accuracy of apex locators: A systematic review.
J Clin Exp Dent
December 2024
Endodontics, Tehran, Iran.
Background: For a successful root canal treatment, it is necessary to determine the correct working length. One of the most used tools to determine the length is: radiography and apex locator. The accuracy of APEX locator of different generations depends on various factors.
View Article and Find Full Text PDFMetabolic Characterization of Sarin, Cyclosarin, and Novichoks (A-230, A-232) in Human Liver Microsomes.
Chem Res Toxicol
January 2025
Collaborations Pharmaceuticals, Inc., 1730 Varsity Drivef, Suite 360, Raleigh, North Carolina 27606-5228, United States.
We have assessed the human liver microsomal (HLM) metabolism of the chemical warfare nerve agents' sarin (GB), cyclosarin (GF), and the Novichok agents A-230 and A-232. In HLM, GB showed drastically decreased stability ( = 1.4 h).
View Article and Find Full Text PDFCytotoxic and antibacterial activity of naturally occurring agglutinin produced from the root of Poir.
Nat Prod Res
January 2025
Bioprocess Engineering Division, Smykon Biotech, Kanniyakumari, Tamilnadu, India.
Lectins are naturally occurring agglutinins which are produced more from plants sources compared to animal sources. The present study aims to screen the potential applications of lectin isolated from the mangrove plant, Poir. This root agglutinin of showed highest HA titre with buffalo erythrocytes.
View Article and Find Full Text PDFQualitative comparison of decalcifiers for mouse bone cryosections for subsequent biophotonic analysis.
Sci Rep
January 2025
Leibniz Institute of Photonic Technology (Member of Leibniz Health Technologies, Member of the Leibniz Centre for Photonics in Infection Research, LPI), 07745, Jena, Germany.
Bone tissue, with its complex structure, often necessitates decalcification of the hard tissue for ex vivo morphological studies. The choice of a suitable decalcification method plays a crucial role in preserving desired features and ensuring compatibility with diverse imaging techniques. The search for a universal decalcification method that is suitable for a range of biophotonic analyses remains an ongoing challenge.
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