Limitations of the traditional manufacturing methods often force engineered components to be made of single material systems. However, this is going through changes due to the advent of additive manufacturing (AM) methods, as the point-by-point consolidation allows for a possible change of the material constitution within a given part domain. This will give rise to a plethora of new material and property options for the designers, where just human perception may fail to realize the full benefits. Automated design tools integrating material choice, dispersion, analysis, and optimization algorithms need to be developed to assist in finding the optimal multi-material dispersion solutions achieving given performance criteria sets. Considering the fact that the multi-material manufacturing systems are only recently coming into use, design solutions targeting optimal placement of multiple materials are not common. This article addresses this gap, evaluating a numerical model integrated with different optimization schemes to find the optimal material solutions achieving certain preset performance criteria such as combinations of natural frequencies in different degrees of freedom. A case study of three different metaheuristic optimization schemes based on genetic algorithms indicates, first, that it is possible to create a beam with six uniformly spaced natural frequencies and to change these frequencies without modifying the structural geometry; and second that the basic genetic algorithm generally outperforms neural net-based alternatives for this problem. This tailoring of the structural resonance spectrum demonstrates that evolutionary computing combined with multi-material AM can be used to unlock previously unavailable structural functionality.
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http://dx.doi.org/10.1089/3dp.2020.0114 | DOI Listing |
Biomater Sci
January 2025
Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, India.
Hydroxyapatite (HA), the main inorganic bone component, is the most widely researched bioceramic for bone repair. This paper presents a comprehensive review of recent advancements in HA synthesis methods and their integration into additive manufacturing (AM) processes. Synthesis methodologies discussed include wet, dry, and biomimetic routes, emphasizing their impact on tailoring the physicochemical properties of HA for biomedical applications.
View Article and Find Full Text PDFMethodsX
December 2024
Department of Mechanical Engineering, Mepco Schlenk Engineering College, Sivakasi 626005, Tamil Nadu, India.
This paper provides a thorough analysis of recent advancements and emerging trends in the integration of metal additive manufacturing (AM) within orthopedic implant development. With an emphasis on the use of various metals and alloys, including titanium, cobalt-chromium, and nickel-titanium, the review looks at their characteristics and how they relate to the creation of various orthopedic implants, such as spinal implants, hip and knee replacements, and cranial-facial reconstructions. The study highlights how metal additive manufacturing (AM) can revolutionize the field by enabling customized implant designs that take patient anatomical variances into account.
View Article and Find Full Text PDFJ Biol Eng
January 2025
Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, 24016, USA.
Extracellular vesicles (EVs) are widely investigated for their implications in cell-cell signaling, immune modulation, disease pathogenesis, cancer, regenerative medicine, and as a potential drug delivery vector. However, maintaining integrity and bioactivity of EVs between Good Manufacturing Practice separation/filtration and end-user application remains a consistent bottleneck towards commercialization. Milk-derived extracellular vesicles (mEVs), separated from bovine milk, could provide a relatively low-cost, scalable platform for large-scale mEV production; however, the reliance on cold supply chain for storage remains a logistical and financial burden for biologics that are unstable at room temperature.
View Article and Find Full Text PDFSci Rep
January 2025
Udmurt Federal Research Center of the Ural Branch of RAS, Baramzina str. 34, Izhevsk, 426067, Russia.
Ultrasound can improve the quality of finished products by reducing porosity and enhancing microstructure in selective laser melting, directed energy deposition, and laser beam welding. This study evaluates the efficiency of ultrasound produced by a pulsed laser via the optoacoustic effect. A quantitative model of collapse of vapor-gas bubbles has been developed under the conditions of ultrasonic treatment at near resonance frequencies.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
BIOLab Research Group, Department of Chemistry and Industrial Chemistry, University of Pisa, UdR INSTM - Pisa, Via G. Moruzzi 13, 56124 Pisa, Italy. Electronic address:
Polyelectrolyte complexes (PECs) are self-assembled systems formed from oppositely charged polymers, used to create hydrogels for cell culture. This work was aimed at additive manufacturing 3D hydrogels made of a PEC between chitosan (Cs) and alginate, as well as their investigation for in vitro 3D ovarian cancer modeling. PEC hydrogels stability in cell culture medium demonstrated their suitability for long-term cell culture applications.
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