AI Article Synopsis
- Human adult stem cells and induced pluripotent stem cells are valuable for studying human biology and diseases, and they can form organ-like structures called organoids in supportive environments.
- Organoids have made significant progress in stem cell research but still face challenges such as inconsistency, limited capabilities, and small size.
- Recent advanced methods are being developed to enhance the biological accuracy and relevance of organoids, providing new opportunities for harnessing the potential of stem cells.
Article Abstract
Human adult stem cells and patient-derived induced pluripotent stem cells represent promising tools to understand human biology, development, and disease. Under a permissive environment, stem cell derivatives can self-organize and reconstruct their native milieu, resulting in the creation of organ-like entities known as organoids. Although organoids represent a breakthrough in the stem cell field, there are still considerable shortcomings preventing their widespread use, namely their variability, limited function, and reductionist size. In the past few years, sophisticated methodologies have been proposed to allow the design of organoids with improved biological fidelity and physiological relevance. Here, we summarize these emerging technologies and provide insights into how they can be utilized to fulfill the potential of stem cells.
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| http://dx.doi.org/10.1016/j.tibtech.2022.12.021 | DOI Listing |
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