Titanium dioxide nanoparticles (nano-TiO) are a common environmental pollutant threatening aquatic animals. The natural habitats and cultured environments of groupers make them vulnerable to nanoparticle pollution. In this study, hybrid grouper juveniles were separately exposed to 1 or 10 mg/L nano-TiO for 14 days, and the toxicological response of these groupers were investigated. After nano-TiO exposure, the liver showed apparent histopathology and intestinal goblet cells were also affected. The transcription of antioxidant and apoptosis-related genes were down-regulated, and the inflammatory factor TNF-α was up-regulated in the liver. The metabolite patterns of the liver were disturbed, especially amino acid metabolism. The diversity and composition of the intestinal microbiota were also altered especially the genera Lactobacillus and Nautella. The changes of several intestinal bacteria were correlated with the immune factors and metabolites of respective hosts. We concluded that nano-TiO exposure negatively affects the physiological homeostasis of groupers.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.marpolbul.2023.114600 | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!