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Drug Development.
Alzheimers Dement
December 2024
University of Kentucky Sanders-Brown Center on Aging, Lexington, KY, USA.
Background: The presence of multiple comorbid pathologic features in late-onset dementia has been well documented across cohort studies that incorporate autopsy evaluation. It is likely that such mixed pathology potentially confounds the results of interventional trials that are designed to target a solitary pathophysiologic mechanism in Alzheimer's disease and related dementias (ADRD).
Method: The UK ADRC autopsy database was screened for participants who had previously engaged in therapeutic interventional trials for Alzheimer's disease, vascular cognitive impairment, dementia, and/or ADRD prevention trials from 2005 to the present.
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Background: The emergence of dementia as a global health challenge necessitates an exploration of its unique epidemiological patterns and risk factors in Sub-Saharan Africa (SSA). Amid a growing elderly population, SSA presents an intriguing paradox of lower-than-expected dementia prevalence, prompting a comprehensive review of epidemiological nuances, lifestyle risk factors, cultural influences, and protective factors. This study critically assessed the current state of dementia research in SSA, aiming to inform tailored interventions and policies.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
Background: Low-middle income countries in Latin America, including Brazil, face a higher prevalence of cognitive decline compared to high-income countries, leading to social-economic and healthcare implications. Several studies have showed an association between reduced physical function and cognitive decline. However, there remains a gap in the understanding of this relationship within the older Brazilian population.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Global Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland.
Background: Socioeconomic disparities (SED) influence brain health and dementia. Latin America (LA) is characterized by high SED and a disproportionate prevalence of Alzheimer's disease (AD) and frontotemporal lobe degeneration (FTLD) compared to high-income populations like the United States (US). However, the impact of SED on brain reserve across neurocognitive pathways related to aging and dementia in LA remains unknown.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University of Pennsylvania, Philadelphia, PA, USA.
Background: Historically underrepresented populations experience a disproportionate burden of Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD) compared to White populations. As a salient resource for coping in Black communities, spiritual and religious practice may support better cognitive health, but it is unknown if changes in these practices are related to cognitive decline.
Methods: We analyzed secondary data of cognitively normal (via Consensus Conference at enrollment) older adults in the U.
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