A PHP Error was encountered
Severity: Warning
Message: fopen(/var/lib/php/sessions/ci_sessionmtl9h7j0gsutkf0qdqrjousk3h4fsfug): Failed to open stream: No space left on device
Filename: drivers/Session_files_driver.php
Line Number: 177
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
A PHP Error was encountered
Severity: Warning
Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)
Filename: Session/Session.php
Line Number: 137
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Experimental encephalomyelitis at age 90, still relevant and elucidating how viruses trigger disease.
J Exp Med
Access Health International , Ridgefield, CT, USA.
Published: February 2023
AI Article Synopsis
- A tribute in a journal celebrated the 70th anniversary of a key animal model for disseminated encephalomyelitis (EAE), originally discussed in a 1933 paper by Rivers and colleagues, focusing on viral infection reactions, particularly from smallpox vaccines.
- Recent studies have linked the Epstein-Barr virus to multiple sclerosis through molecular mimicry involving a protein called GlialCAM, highlighting the ongoing relevance of EAE in understanding autoimmune responses.
- The research findings reconnect contemporary insights with foundational work on EAE, showcasing the lasting impact of Rivers' original contributions nearly 90 years later.
Article Abstract
20 yr ago, a tribute appeared in this journal on the 70th anniversary of an animal model of disseminated encephalomyelitis, abbreviated EAE for experimental autoimmune encephalomyelitis. "Observations on Attempts to Produce Disseminated Encephalomyelitis in Monkeys" appeared in the Journal of Experimental Medicine on February 21, 1933. Rivers and colleagues were trying to understand what caused neurological reactions to viral infections like smallpox, vaccinia, and measles, and what triggered rare instances of encephalomyelitis to smallpox vaccines. The animal model known as EAE continues to display its remarkable utility. Recent research, since the 70th-anniversary tribute, helps explain how Epstein-Barr virus triggers multiple sclerosis via molecular mimicry to a protein known as GlialCAM. Proteins with multiple domains similar to GlialCAM, tenascin, neuregulin, contactin, and protease kinase C inhibitors are present in the poxvirus family. These observations take us a full circle back to Rivers' first paper on EAE, 90 yr ago.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880878 | PMC |
| http://dx.doi.org/10.1084/jem.20221322 | DOI Listing |
Similar Publications
Beyond genotype: challenges in predicting disease risk for carriers of biallelic perforin variants.
Blood
March 2025
CIBSS - Center for Integrative Biological Signalling Studies, University of Freiburg, Germany, Germany.
Genetic screening for severe congenital immuno-hematological diseases offers potential for early intervention, particularly through preemptive allogeneic stem cell transplantation (HSCT). However, the clinical value of such screening depends on precise prognostic predictions based on genotype-phenotype correlations and/or functional confirmation. We investigated familial hemophagocytic lymphohistiocytosis type 2 (FHL2), caused by PRF1 variants.
View Article and Find Full Text PDFA multiple regression model for peak skin dose using principal component analysis in interventional radiology.
Radiol Phys Technol
March 2025
Department of Neurosurgery, Division of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, 5200 Kihara Kiyotake-Cho, Miyazaki, 889-1692, Japan.
This study addresses the growing concerns of increased radiation doses to patients resulting from the increased complexity of interventional radiology procedures. Despite the importance of dose management, few facilities use dosimetry systems to measure and control patient radiation doses. To aid in patient exposure control, this research aimed to predict the peak skin dose (PSD) using dose parameters from digital imaging and communication in medicine-radiation dose structured reports.
View Article and Find Full Text PDFCost-effectiveness of nintedanib versus Pirfenidone in the treatment of idiopathic pulmonary fibrosis: a systematic review.
Expert Rev Pharmacoecon Outcomes Res
March 2025
Department of Health Services Management, School of Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.
Introduction: Objective: To systematically review studies on the cost-effectiveness of pirfenidone compared to nintedanib in patients with idiopathic pulmonary fibrosis (IPF).
Methods: Data sources: PubMed, EMBASE, Scopus, and Web of Science. Inclusion criteria: Full economic evaluations comparing pirfenidone versus nintedanib in IPF patients.
This article describes the first experience of successful use of growth hormone (GH) in combination with an aromatase inhibitor (AI), in a 14-year-old boy. At the age of 7, he presented with headaches, nausea and vomiting, and MRI revealed a craniopharyngioma (CP). An Ommaya system was implanted, and radiation therapy was performed.
View Article and Find Full Text PDFBackground: Self-monitoring of blood glucose (SMBG) is the main tool to achieve carbohydrate metabolism targets in patients with type 1 diabetes mellitus (DM). Remote monitoring of SMBG in Russia appeared relatively recently and needs to be evaluated for effectiveness.
Aim: To evaluate the effect of remote monitoring of SMBG on carbohydrate metabolism and quality of life in patients with type 1 DM in order to form new therapeutic approaches.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.