Hereditary hypotrichosis simplex is a rare genetic hair disease that affects the scalp. Failure to grow normal hair in terms of length and density is the main complaint of patients. Diagnosis usually established by exclusion of other congenital hair and other ectodermal disorders. Till now, no satisfactory treatment was used for the condition. A 14 year old patient with hypotrichosis simplex was treated with combined platelet rich plasma injection and topical minoxidil 2% with marked improvement. While no satisfactory treatment presents for this condition, the use of platelet rich plasma injection can add new hope for hypotrichosis simplex patients.
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http://dx.doi.org/10.1080/09546634.2023.2169575 | DOI Listing |
Indian J Dermatol Venereol Leprol
November 2024
Department of Dermatology, School of Medicine, Pusan National University, Seo-Gu, Busan, Republic of Korea, Korea.
JAAD Case Rep
September 2024
Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
J Cosmet Dermatol
December 2024
Center for bioinformatics, National Infrastructures for Translational Medicine, Peking Union Medical College Hospital, Beijing, China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
March 2024
Department of Dermatology, Jining No.1 People's Hospital, Jining, Shandong 272002, China.
Objective: To explore the clinical phenotype and genetic characteristics of a child with Hypotrichosis 14.
Methods: A child who had presented at the Henan Provincial People's Hospital on May 4, 2020 due to hair thinning was selected as the study subject. Clinical data of the child was collected.
Am J Med Genet A
September 2023
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
Congenital cataract is the most common cause of lifelong visual loss in children worldwide, which has significant genotypic and phenotypic heterogeneity. The LSS gene encodes lanosterol synthase (LSS), which acts on the cholesterol biosynthesis pathway by converting (S)-2,3-oxidosqualene to lanosterol. The biallelic pathogenic variants in the LSS gene were found in congenital cataract, Alopecia-intellectual disability syndrome, hypotrichosis simplex, and mutilating palmoplantar keratoderma.
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