AI Article Synopsis
- Researchers are studying treatment options for gastric cancer patients with para-aortic lymph node (PAN) metastasis, which is usually considered inoperable; they're focusing on cases limited to specific lymph node regions No.16a2/b1.
- The treatment plan involves a combination of preoperative therapy (nab-paclitaxel, oxaliplatin, and S-1), followed by D2 gastrectomy with PAN dissection, and then additional postoperative therapies.
- The study aims to evaluate the effectiveness of this approach through various measures, including overall survival rates, disease-free survival, and the frequency of complications.
Article Abstract
Although gastric cancer with para-aortic lymph node (PAN) metastasis is commonly regarded as unresectable, surgeons have explored the optimal treatment for patients with PAN metastases limited to No.16a2/b1 in the past few decades. Preoperative systemic therapy combined with D2 gastrectomy plus PAN dissection may improve the prognosis of these patients. In this multicenter phase II trial, 29 gastric cancer patients with PAN metastasis limited to No.16a2/b1 will receive preoperative treatment with nab-paclitaxel, oxaliplatin, S-1 (nab-POS: nab-paclitaxel, oxaliplatin, S-1) and sintilimab followed by D2 gastrectomy plus PAN dissection; and postoperative treatment with oral S-1, intravenous sintilimab and intraperitoneal paclitaxel. The end points for the study are 3-year overall survival, 3-year disease-free survival, pathological response rate, incidence of postoperative complications and adverse events.
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| http://dx.doi.org/10.2217/fon-2022-0718 | DOI Listing |
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