AI Article Synopsis
- Statins, like rosuvastatin, are commonly used to prevent cardiovascular diseases but can cause muscle-related side effects that lead to patients not sticking to their treatment.
- Different patient groups metabolize rosuvastatin differently due to genetic variations, particularly in certain Asian populations where a specific missense variant is more prevalent.
- This genetic variability suggests that rosuvastatin dosing should shift from race-based approaches to genotype-based strategies, emphasizing the need for tailored starting doses, especially lower ones for Filipinos.
Article Abstract
Statins are widely used medications for the primary and secondary prevention of cardiovascular diseases. Statin-induced musculoskeletal symptoms are the primary adverse drug events contributing to poor adherence to lipid-lowering therapy. Rosuvastatin is characterized by interindividual differences in systemic exposure among different patient population subgroups. The missense variant within , highly prevalent in some Asian subgroups, results in decreased transporter efflux function and increased exposure to rosuvastatin. We aim to highlight the implications of genotype in prescribing rosuvastatin and the ramifications of interpopulation differences in frequencies in the starting dose of rosuvastatin in major Asian subgroups, using the most recent genetic-based guidelines. The high frequency of in Filipinos could warrant a lower starting rosuvastatin dose versus non-Filipinos. The genotype frequencies in Asian subgroups suggest significant interpopulation differences, reinforcing the need to move beyond race-based to genotype-based rosuvastatin dosing.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979151 | PMC |
| http://dx.doi.org/10.2217/pgs-2022-0155 | DOI Listing |
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