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Coordinated regulation of eosinophil production and migration by glucocorticoids, prostaglandins, and cysteinyl-leukotrienes.
Int Immunopharmacol
January 2025
Laboratório de Citocinas Dept. of Immunology Instituto de Microbiologia Prof. Paulo de Góes Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil.
Introduction: The spectrum of eosinophil functions has expanded from fighting helminths to multiple novel roles in malignancy, infection, cancer, and metabolism. In asthma, glucocorticoids, prostaglandins (PG), and cysteinyl-leukotrienes (LT) regulate eosinophil biology through separate signaling pathways. Here we've evaluated the complex interplay between Dexa, PGE2, and CysLTs in eosinopoiesis and eosinophil biology in an allergic asthma model.
View Article and Find Full Text PDFGlucocorticoid promotes metastasis of colorectal cancer via co-regulation of glucocorticoid receptor and TET2.
Int J Cancer
December 2024
HIM-BGI Omics Center, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences (CAS), Hangzhou, China.
Glucocorticoids (GCs), commonly used for anti-inflammatory and cancer treatments, have been linked to the promotion of cancer metastasis. Yet, the molecular mechanisms behind this potential remain poorly understood. Clarifying these mechanisms is crucial for a nuanced understanding and potential refinement of GC therapies in the context of cancer treatment.
View Article and Find Full Text PDFTopical dexamethasone decelerates epithelial migration on the canine tympanic membrane.
Vet Dermatol
December 2024
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea.
Background: Epithelial migration (EM) is integral to normal ear structure and function. Glucocorticoids are considered the first-line therapy for various external ear disorders; however, their effects on EM on the tympanic membrane (TM) and the external auditory canal (EAC) are understudied.
Hypothesis/objectives: To test the hypothesis that topical dexamethasone decelerates EM on the TM, this study aimed to evaluate the effects of topical dexamethasone on EM on the TMs of dogs.
Dysregulation of septin cytoskeletal organization in the trabecular meshwork contributes to ocular hypertension.
JCI Insight
December 2024
Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA.
Article Synopsis
- Ocular hypertension, a key risk factor for glaucoma, is linked to increased activity and stiffness in the trabecular meshwork (TM) due to cellular interactions.
- Previous research identified high levels of septin-9 in TM cells under hypertensive conditions, prompting studies on its overexpression, deficiency, and drug targeting effects.
- Findings indicate that septin-9 impacts intraocular pressure (IOP) regulation, suggesting that modulating septin cytoskeletal organization could be a potential new treatment strategy for glaucoma.
Prenatal glucocorticoid exposure and congenital abdominal wall defects: Involvement of CXCR4 - SDF-1 signaling.
Mech Ageing Dev
February 2025
Department of Anatomy and Molecular Embryology, Institute of Anatomy, Medical Faculty, Ruhr University Bochum, Bochum, Germany. Electronic address:
Developmental defects of the ventral abdominal wall, such as gastroschisis, have been associated with prenatal stress exposure. To investigate this further, dexamethasone (DEX), a synthetic glucocorticoid, was administered to fertilized chicken eggs on day 1 of incubation to simulate stress, and embryonic development was subsequently analyzed through in-situ hybridization, immunohistochemistry, and histological methods. Significant developmental abnormalities were displayed by DEX-treated embryos, including open abdomens, reduced MYOG expression in the abdominal wall, and disrupted muscle fiber formation, as indicated by altered Myosin heavy chain patterns.
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