Air pollution is a serious environmental problem that damages public health. In the present study, we used the segmentation function to improve the health risk-based air quality index (HAQI) and named it new HAQI (NHAQI). To investigate the spatiotemporal distribution characteristics of air pollutants and the associated health risks in Shaanxi Province before (Period I, 2015-2019) and after (Period II, 2020-2021) COVID-19. The six criteria pollutants were analyzed between January 1, 2015, and December 31, 2021, using the air quality index (AQI), aggregate AQI (AAQI), and NHAQI. The results showed that compared with AAQI and NHAQI, AQI underestimated the combined effects of multiple pollutants. The average concentrations of the six criteria pollutants were lower in Period II than in Period I due to reductions in anthropogenic emissions, with the concentrations of PM (particulate matter ≤2.5 μm diameter), PM (PM ≤ 10 μm diameter) SO, NO, O, and CO decreased by 23.5%, 22.5%, 45.7%, 17.6%, 2.9%, and 41.6%, respectively. In Period II, the excess risk and the number of air pollution-related deaths decreased considerably by 46.5% and 49%, respectively. The cumulative population distribution estimated using the NHAQI revealed that 61% of the total number of individuals in Shaanxi Province were exposed to unhealthy air during Period I, whereas this proportion decreased to 16% during Period II. Although overall air quality exhibited substantial improvements, the associated health risks in winter remained high.
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http://dx.doi.org/10.1016/j.envpol.2023.121090 | DOI Listing |
Microbiology (Reading)
January 2025
Department of Zoology, University of British Columbia, Vancouver, Canada.
Microbiome-animal host symbioses are ubiquitous in nature. Animal-associated microbiomes can play a crucial role in host physiology, health and resilience to environmental stressors. As climate change drives rising global temperatures and increases the frequency of thermal extremes, microbiomes are emerging as a new frontier in buffering vulnerable animals against temperature fluctuations.
View Article and Find Full Text PDFJ Clin Invest
January 2025
Center for Inherited Myology Research, Virginia Commonwealth University, Richmond, United States of America.
Background: Myotonic dystrophy type 1 (DM1) is a multisystemic, CTG repeat expansion disorder characterized by a slow, progressive decline in skeletal muscle function. A biomarker correlating RNA mis-splicing, the core pathogenic disease mechanism, and muscle performance is crucial for assessing response to disease-modifying interventions. We evaluated the Myotonic Dystrophy Splice Index (SI), a composite RNA splicing biomarker incorporating 22 disease-specific events, as a potential biomarker of DM1 muscle weakness.
View Article and Find Full Text PDFPhys Ther
January 2025
IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
Importance: Rotator cuff tendinopathy represents the most prevalent cause of shoulder pain, the third most common musculoskeletal disorder after low back pain and knee pain.
Objective: The objective of this study was to determine the effectiveness of corticosteroid injection(s), alone or in combination with anesthetic injection or any other physical therapist interventions, compared to physical therapist interventions alone in adults with rotator cuff tendinopathy.
Design: This study was a systematic review and meta-analysis of randomized controlled trials.
JAMA Netw Open
January 2025
Department of Global Health, School of Public Health, Boston University, Boston, Massachusetts.
Importance: Semaglutide, a novel glucagon-like peptide-1 (GLP-1) receptor agonist medication, was approved for weight management in individuals with obesity in June 2021. There is limited evidence on factors associated with uptake among individuals in this subgroup without diabetes.
Objective: To explore factors associated with semaglutide initiation among a population of commercially insured individuals with obesity but no diagnosed diabetes.
JAMA Netw Open
January 2025
Division of Endocrinology and Metabolism, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
Importance: Using albumin-adjusted calcium is commonly recommended for for measuring calcium, but with little empirical evidence to support the practice.
Objective: To assess the correlation between total calcium measurements (with or without adjustment) vs the ionized calcium level as a reference standard.
Design, Setting, And Participants: This was a population-based cross-sectional study in the province of Alberta, Canada, including adults tested for serum total calcium and ionized calcium simultaneously between January 1, 2013, and October 31, 2019.
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