Cognitive Disorders/Dementia Unit, 2nd Department of Neurology, Attikon University General Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Chaidari, Greece.
Published: December 2022
AI Article Synopsis
Article Abstract
Background: the apolipoprotein e4 allele () constitutes an established genetic risk factor for Alzheimer's Disease Dementia (ADD). We aimed to explore the frequency of the isoforms in the Greek population of Southern Greece.
Methods: peripheral blood from 175 Greek AD patients, 113 with mild cognitive impairment (MCI), and 75 healthy individuals. DNA isolation was performed with a High Pure PCR Template Kit (Roche), followed by amplification with a real-time qPCR kit (TIB MolBiol) in Roche's Light Cycler PCR platform.
Results: allele frequency was 20.57% in the ADD group, 17.69% in the MCI group, and 6.67% in the control group. homozygosity was the most common genotype, while the frequency of homozygosity was higher in the AD group (8.60%). carrier status was associated with higher odds for ADD and MCI (OR: 4.49, 95% CI: [1.90-10.61] and OR: 3.82, 95% CI: [1.59-9.17], respectively).
Conclusion: this study examines the isoforms and is the first to report a higher frequency in MCI compared with healthy controls in southern Greece. Importantly, we report the occurrence of the allele, related to ADD, as amongst the lowest globally reported, even within the nation, thus enhancing the theory of ethnicity and latitude contribution.
Sweetpotato (Ipomoea batatas L.), an important food and industrial crop in the world, has a highly heterozygous hexaploid genome, making the development of single nucleotide polymorphism (SNP) markers challenging. Identifying SNP loci and developing practical SNP markers are crucial for genomic and genetic research on sweetpotato.
Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, Rua do Matão, 277, CEP 05508-090, São Paulo, SP, Brazil.
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Material And Methods: this study comprehensively searched multiple databases from inception to March 31, 2024.
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