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| http://dx.doi.org/10.1172/JCI168068 | DOI Listing |
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Cancer immunotherapy using engineered cytotoxic effector cells has demonstrated significant potential. The limited spatial complexity of existing models, however, poses a challenge to mechanistic studies attempting to approve existing approaches of effector cell-mediated cytotoxicity within a three-dimensional, solid tumor-like environment. To gain additional experimental control, we developed an approach for constructing three-dimensional (3D) culture models using smart polymers that form temperature responsive hydrogels.
View Article and Find Full Text PDFDespite the sequencing revolution, large swaths of the genomes sequenced to date lack any information about the arrangement of transcription factor binding sites on regulatory DNA. Massively Parallel Reporter Assays (MPRAs) have the potential to dramatically accelerate our genomic annotations by making it possible to measure the gene expression levels driven by thousands of mutational variants of a regulatory region. However, the interpretation of such data often assumes that each base pair in a regulatory sequence contributes independently to gene expression.
View Article and Find Full Text PDFIt is now possible to generate large volumes of high-quality images of biomolecules at near-atomic resolution and in near-native states using cryogenic electron microscopy/electron tomography (Cryo-EM/ET). However, the precise annotation of structures like filaments and membranes remains a major barrier towards applying these methods in high-throughput. To address this, we present TARDIS ( ransformer-b sed apid imensionless nstance egmentation), a machine-learning framework for fast and accurate annotation of micrographs and tomograms.
View Article and Find Full Text PDFLipid nanoparticles (LNPs) are the most advanced delivery system currently available for RNA therapeutics. Their development has accelerated since the success of Patisiran, the first siRNA-LNP therapeutic, and the mRNA vaccines that emerged during the COVID-19 pandemic. Designing LNPs with specific targeting, high potency, and minimal side effects is crucial for their successful clinical use.
View Article and Find Full Text PDFAir pollution exposure disparities across age groups in Beijing-Tianjin-Hebei region from 2010 to 2020.
Environ Pollut
January 2025
School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an 710049, China.
Air pollution carries different disease burdens across all age groups, with the elderly and children being the most affected. Therefore, it is of practical significance to study air pollution exposure characteristics of different age groups in the context of accelerating aging in China. In this study, we used the number of people and air pollutant concentration data at the township-level scale (the smallest administrative unit in China) to calculate population-weighted PM concentration exposure (PM PWE) values of different age groups in the Beijing-Tianjin-Hebei (BTH) region, quantified the pollution exposure differences among different groups, and analyzed the spatiotemporal changes in such differences and their driving factors.
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