Using host-guest interactions between β-cyclodextrin-modified branched polyethyleneimine and ferrocene-terminated poly-L-lactide, the formation, assembly and jamming of polyethyleneimine surfactants (PEISs) at the liquid-liquid interface is presented. With PEIS, reconfigurable liquids with electrochemical redox responsiveness can be constructed. In conjunction with microfluidic methods, continuous, selective diffusion and purification of ionic species can be achieved in all-liquid constructs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d2sm01559e | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intracranial Nanogel Pellets Carrying Temozolomide and Paclitaxel for Adjuvant Brain Cancer Therapy.
Mol Pharm
January 2025
Industrial Pharmacy, Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, New York 11439, United States.
Glioblastoma multiforme is the most frequently diagnosed primary malignant brain tumor. Despite multimodal therapy with surgical resection, radiation therapy, and chemotherapy, recurrence of the tumor is almost always guaranteed due to the infiltrative nature of the disease. Moreover, the blood brain barrier imparts an additional layer of complexity by impeding the delivery of therapeutic agents to the tumor, hence limiting the efficacy of systemically delivered drugs.
View Article and Find Full Text PDFShape Effect of Polymer-Based Multilayer Microcapsules on Cellular Internalization.
Langmuir
December 2024
Joint Research Centre on Medicine, Xiangshan Hospital of Wenzhou Medical University, Ningbo, Zhejiang 315700, China.
The intracellular fate of drug carriers had received extensive attention, which was profoundly influenced by the shapes of carriers. However, it has not been fully addressed due to the lack of effective strategies to prepare carriers with different shapes and the interference of other parameters (such as stiffness and chemistry of the shaped particle and the different cell lines). In this work, polymer-based microcapsules with different shapes (spherical, peanut, dumbbell, and cubic) but the same surface chemistry were engineered through the alternative deposition of polyethylenimine (PEI) and polyethylene glycol (PEG) onto the sacrificial CaCO templates with different well-defined shapes.
View Article and Find Full Text PDFOral creatine-modified selenium-based hyaluronic acid nanogel mediated mitochondrial energy recovery to drive the treatment of inflammatory bowel disease.
J Nanobiotechnology
November 2024
Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, P. R. China.
Article Synopsis
- Mitochondrial dysfunction plays a significant role in inflammatory bowel disease (IBD), yet there are limited reports on targeted treatments that address this issue.
- Researchers developed a novel oral treatment called HA-Cr nanogel, which combines selenium and creatine to enhance mitochondrial energy metabolism and eliminate reactive oxygen species (ROS) specifically at inflammation sites.
- The HA-Cr nanogel showed promising results in improving IBD symptoms by restoring mitochondrial function, reducing inflammatory macrophage activity, repairing gut mucosa, and supporting microbial health, suggesting a new avenue for IBD treatment.
Design of enzyme immobilized zwitterionic copolymer nanogels and its size effect on electrochemical reaction.
Colloids Surf B Biointerfaces
February 2025
Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. Electronic address:
For enzyme-based electrochemical devices, an improvement in electron transfer between the enzyme and electrode is important. Thus, we developed a nano-scaled hydrogel that includes an electron mediator and enzyme to realize nano-sized effects that enhance the functions. Three different chain lengths (short, medium, and long) of copolymers composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) and methacrylic acid N-hydroxysuccinimide ester (MNHS; poly(MPC-co-MNHS), PMS) were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization.
View Article and Find Full Text PDFConstruction of an Innovative Nanogel and Its Applications for Achieving Chemo-Immunotherapy of Tumors.
ACS Appl Mater Interfaces
November 2024
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
Malignant tumors, also known as cancers, are a global public health problem. Nanogels are promising carriers for the delivery of anticancer medicines. Therefore, based on the unique microenvironment of tumor cells and the advantages of nanogels, a simple and economical one-pot synthesis method was designed to construct natural polysaccharide-based redox-responsive nanogels (LDD NGs).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!