AI Article Synopsis
- Eosinophilic pustular folliculitis (EPF) is a rare, chronic skin condition that is non-infectious and often linked to other health issues like HIV and syphilis.
- A case study highlights the first known instance of EPF occurring in a patient with syphilis, suggesting a connection between the two conditions through similar immune responses.
- The patient, a 48-year-old man, had symptoms that included redness and pustules on his face and neck, which improved significantly after treatment, though some skin pigmentation remained.
Article Abstract
Eosinophilic pustular folliculitis (EPF) is a rare, chronic, non-infectious inflammatory skin disease. Although the pathogenesis of EPF is unknown, eosinophilic pustular folliculitis may be associated with human immunodeficiency virus (HIV) infection, malignancies or syphilis. Here, we report the first case of EPF associated with syphilis, indicating that syphilis and EPF are correlated with T-helper type 2 immune responses. A 48-year-old man gradually developed erythema and pustules on the face, neck. Physical examination revealed multiple infiltrative red patches and plaques on the face, neck with tiny pustules. Skin biopsy results revealed that the dermal follicular sebaceous gland unit was infiltrated by a large number of neutrophils and eosinophils, forming eosinophilic microabscesses. Therefore, the patient was diagnosed with EPF associated with syphilis and received drug treatment. After the treatment, the pustules markedly decreased, leaving behind pigmentation. Furthermore, the patient is still being followed up.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840400 | PMC |
| http://dx.doi.org/10.2147/CCID.S393841 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Immunohistochemical Analyses of Monkeypox Skin Lesions with MPXV A29 and A35 Antibodies: A Novel Insight for Clinical-Histopathological Forms.
Jpn J Infect Dis
October 2024
Department of Sexually Transmitted Disease, Shanghai Skin Disease Hospital, Tongji University School of Medicine, China.
The aim of this study was to describe the clinical, histopathological, and immunohistochemical characteristics of MPX and offer meaningful insights into the clinicopathology of MPX. We recruited eight men who had sex with men diagnosed with MPX based on positive results from MPX Virus (MPXV)-specific polymerase chain reaction. Skin biopsies were obtained from four selected lesions, including typical and atypical lesions.
View Article and Find Full Text PDFNovel association of eosinophilic pustular folliculitis with systemic lupus erythematosus: A case report.
JAAD Case Rep
October 2024
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
Two cases of eosinophilic pustular folliculitis successfully treated with abrocitinib.
J Dermatol
December 2024
Dermatology Hospital of Southern Medical University, Guangzhou, China.
Article Synopsis
- Eosinophilic pustular folliculitis (EPF) is a rare inflammatory skin disease mainly involving eosinophils and can appear in both follicle areas and less commonly in follicle-free areas.
- This case study details two patients with difficult-to-treat EPF who had previous treatment failures with various standard therapies.
- Both patients responded positively to the medication abrocitinib, achieving complete remission in one week and four weeks, with no side effects reported, suggesting it could be a safe treatment option for EPF.
Mepolizumab therapy for eosinophilic pustular folliculitis (Ofuji disease).
J Eur Acad Dermatol Venereol
November 2024
Dermatology Clinic, Maggiore Hospital, University of Trieste, Trieste, Italy.
Genetic analysis of different subtypes of aseptic pustulosis in the Chinese population.
Clin Exp Dermatol
September 2024
Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Article Synopsis
- Aseptic pustulosis consists of inflammatory skin conditions characterized by nonbacterial pustules and increased neutrophil and eosinophil presence in the skin.
- Research indicates that disruptions in the interleukin-36 pathway play a critical role in neutrophil aggregation and pustule development.
- The study identifies strong genetic links between IL36RN variants and various forms of aseptic pustulosis, highlighting potential therapeutic targets in the IL-1/IL-36-chemokine-neutrophil pathway.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!