AI Article Synopsis
- Aging leads to a decline in biological functions, increasing the risk of diseases and mortality, and non-coding RNAs, particularly tRNA-derived small RNAs (tsRNAs), play a significant role in this process.
- The review highlights how levels and functions of tsRNAs change with age and their involvement in age-related diseases like cancer and neurodegenerative diseases.
- Additionally, tsRNAs are linked to critical aging processes, such as mitochondrial respiration and cellular senescence, and the review offers insights into their potential roles in understanding aging and associated diseases.
Article Abstract
Aging is characterized by a gradual decline in biological functions, leading to the increased probability of diseases and deaths in organisms. Previous studies have identified biological factors that modulate aging and lifespan, including non-coding RNAs (ncRNAs). Here, we review the relationship between aging and tRNA-derived small RNAs (tsRNAs), ncRNAs that are generated from the cleavage of tRNAs. We describe age-dependent changes in tsRNA levels and their functions in age-related diseases, such as cancer and neurodegenerative diseases. We also discuss the association of tsRNAs with aging-regulating processes, including mitochondrial respiration and reduced mRNA translation. We cover recent findings regarding the potential roles of tsRNAs in cellular senescence, a major cause of organismal aging. Overall, our review will provide useful information for understanding the roles of tsRNAs in aging and age-associated diseases. [BMB Reports 2023; 56(2): 49-55].
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9978369 | PMC |
| http://dx.doi.org/10.5483/BMBRep.2022-0199 | DOI Listing |
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