Carbon nanomaterials: A growing tool for the diagnosis and treatment of diabetes mellitus.

Environ Res

School of Engineering, Lebanese American University, Byblos, Lebanon; University Centre for Research & Development, Department of Civil Engineering, Chandigarh University, Mohali, India. Electronic address:

Published: March 2023

Diabetes mellitus is a growing disease that affects people of different ages due to deficiencies in insulin action and secretion. Diabetes causing long-term hyperglycemia damages, destroys, and fails essential organs, including kidneys, eyes, hearts, nerves, and blood vessels. The involvement of pathogenic factors makes diabetes mellitus a severe disease. The autoimmune process results in insulin deficiency by destroying the beta-cells in the pancreas. This leads to insulin resistance. As a result of defects and abnormalities in fat, carbohydrate, and protein synthesis, insulin does not work as it should on the target tissues. As diabetes mellitus becomes, more severe, long-term and effective treatment becomes necessary. A wide range of nanomaterials can be used to treat diabetes mellitus in patients. In addition to being potential imaging, diagnostic, and treatment agents for diabetes mellitus, carbon nanomaterials (CNMs) are another group of nanoparticles that exhibit potential interest. The CNMs acts as implantable nanosensor to track and detect blood glucose level in patients with diabetes. CNMS are possible drug carriers that can treat diabetes mellitus selectively, precisely, and effectively. Diabetes mellitus can be diagnosed and treated with CNMs due to their structural specificity and high drug-loading efficiency. The present review explores CNMs for their types, synthesis, and anti-diabetic properties. This review aims to provide a detailed view of the new technology that can be used to decipher the mechanism of CNMs in diabetes mellitus.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envres.2023.115250DOI Listing

Publication Analysis

Top Keywords

diabetes mellitus
36
diabetes
11
mellitus
9
carbon nanomaterials
8
mellitus severe
8
treat diabetes
8
cnms
6
nanomaterials growing
4
growing tool
4
tool diagnosis
4

Similar Publications

Objectives: This case-control study aims to clarify the impact of single nucleotide polymorphisms (SNPs) within the P2X7 gene on susceptibility to type 2 diabetes mellitus (T2DM) and to evaluate their association with diabetic complications.

Methods: This study is comprised with 200 T2DM cases and 200 healthy controls. Seven candidate SNP loci were screened, and TaqMan-MGB real-time PCR technology was used to determine the polymorphic variants of P2X7.

View Article and Find Full Text PDF

Patients with type 1 diabetes and their physicians have long desired a fully closed-loop artificial pancreas (AP) system that can alleviate the burden of blood glucose regulation. Although deep reinforcement learning (DRL) methods theoretically enable adaptive insulin dosing control, they face numerous challenges, including safety and training efficiency, which have hindered their clinical application. This paper proposes a safe and efficient adaptive insulin delivery controller based on DRL.

View Article and Find Full Text PDF

Essential Thrombocythemia: A Review.

JAMA

January 2025

CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy.

Importance: Essential thrombocythemia, a clonal myeloproliferative neoplasm with excessive platelet production, is associated with an increased risk of thrombosis and bleeding. The annual incidence rate of essential thrombocythemia in the US is 1.5/100 000 persons.

View Article and Find Full Text PDF

Modulation of placental angiogenesis by metformin in a rat model of gestational diabetes.

Histochem Cell Biol

January 2025

Medical Histology and Cell Biology Department, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.

Gestational diabetes mellitus (GDM) significantly disrupts placental structure and function, leading to complications such as intrauterine growth restriction (IUGR) and preeclampsia. This study aimed to investigate the effects of GDM on placental histology, angiogenesis, and oxidative stress, as well as evaluate metformin's protective role in mitigating these changes. A total of 60 pregnant Sprague-Dawley rats were divided into four groups: control, metformin-treated, GDM, and GDM with metformin.

View Article and Find Full Text PDF

Subtypes of Insulin Restriction in Diabetes Management: A Systematic Review.

Curr Diab Rep

January 2025

Department of Psychological Sciences, University of California, Merced, CA, USA.

Purpose Of Review: Insulin restriction is commonly studied as a form of disordered eating, but people may restrict insulin for many reasons. This systematic review examined how insulin restriction has been conceptualized and measured, and its associated predictors and outcomes.

Recent Findings: Forty-seven unique articles measured non-specified insulin restriction (IR), insulin restriction specifically for weight control (IRWC), or both.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!