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Artesunate alleviates radiation-induced submandibular gland epithelial cell damage in rats by reducing inflammation and apoptosis.
Cell Biol Int
November 2024
College & Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China.
Salivary hypofunction is a common complication in patients with head and neck cancers following radiotherapy (RT). RT-induced inflammation in salivary gland cells leads to apoptosis and fibrosis. Artesunate (ART) is a bioactive compound with anti-inflammatory and anti-fibrosis properties.
View Article and Find Full Text PDFImportant functions and molecular mechanisms of aquaporins family on respiratory diseases: potential translational values.
J Cancer
October 2024
Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, 362000, China.
Aquaporins (AQPs) are a subgroup of small transmembrane transporters that are distributed in various types of tissues, including the lung, kidney, heart and central nervous system. It is evident that respiratory diseases represent a significant global health concern, with a considerable number of deaths occurring worldwide. Recent researches have demonstrated that AQPs play a pivotal role in respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, acute respiratory distress syndrome (ARDS), and particularly non-small cell lung cancer (NSCLC).
View Article and Find Full Text PDFIL-37 Inhibits Inflammation of Lacrimal Gland in Dry Eye Mice via the IL-37-PTEN-NFκB Signaling Pathway.
Ocul Immunol Inflamm
December 2024
Department of Ophthalmology, The Second Hospital of Anhui Medical University, Hefei, Anhui, China.
Purpose: This study aims to investigate the role of Interleukin-37 (IL-37) in mouse models of dry eye.
Methods: Two murine models of dry eye were employed in this investigation. The evaluation of the anti-inflammatory impact of IL-37 (200 μl, 10 μg/ml) on dry eye mice involved intraperitoneal injections administered once daily for 7 days.
Deciphering Molecular Mechanisms Involved in the Modulation of Human Aquaporins' Water Permeability by Zinc Cations: A Molecular Dynamics Approach.
Int J Mol Sci
February 2024
Laboratoire de Physiologie, Ecologie et Environnement (P2E), UPRES EA 1207/USC INRAE-1328, UFR Sciences et Techniques, Université d'Orléans, F-45067 Orléans, France.
Aquaporins (AQPs) constitute a wide family of water channels implicated in all kind of physiological processes. Zinc is the second most abundant trace element in the human body and a few studies have highlighted regulation of AQP0 and AQP4 by zinc. In the present work, we addressed the putative regulation of AQPs by zinc cations in silico through molecular dynamics simulations of human AQP0, AQP2, AQP4, and AQP5.
View Article and Find Full Text PDFER-1 deficiency induces inflammation and lipid deposition in meibomian gland and lacrimal gland.
Biochem Biophys Res Commun
February 2024
Department of Ophthalmology, The Second Hospital of Anhui Medical University, Hefei, Anhui, China. Electronic address:
Purpose: To investigated the role of estrogen receptor-1 (ER-1) in maintaining homeostasis in ocular surface.
Methods: ER-1-knockout (ER-1KO) mice were studied at 4 months of age. The ocular surface was examined using a slit lamp.
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