AI Article Synopsis
- TET proteins are enzymes that play a key role in modifying DNA by converting 5-methylcytosine to 5-hydroxymethylcytosine, which is important for DNA demethylation in immune cells.
- Recent research emphasizes the significance of TET proteins in regulating gene expression related to T cell development, function, and growth.
- The study also explores ongoing questions about the roles of TET proteins across different biological systems and their potential implications for improving treatments for diseases like blood cancers and immune responses to tumors.
Article Abstract
Ten-eleven translocation (TET) proteins are dioxygenases that oxidize 5-methylcytosine to form 5-hydroxymethylcytosine and downstream oxidized modified cytosines. In the past decade, intensive research established that TET-mediated DNA demethylation is critical for immune cell development and function. In this study, we discuss major advances regarding the role of TET proteins in regulating gene expression in the context of T cell lineage specification, function, and proliferation. Then, we focus on open questions in the field. We discuss recent findings regarding the diverse roles of TET proteins in other systems, and we ask how these findings might relate to T cell biology. Finally, we ask how this tremendous progress on understanding the multifaceted roles of TET proteins in shaping T cell identity and function can be translated to improve outcomes of human disease, such as hematological malignancies and immune response to cancer.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152628 | PMC |
| http://dx.doi.org/10.4049/immunohorizons.2200067 | DOI Listing |
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