A new alkaloid, neohelicomyine A (), along with two known alkaloids (-), were isolated from the fermentation of PF11-1. The structures of these compounds were elucidated by extensive analyses of spectroscopic methods including 1 D and 2 D NMR, HRESIMS and ECD. The bioactivities of all compounds were evaluated using cellular assays, and compounds and displayed moderate cytotoxicities against human cancer (A549, TCA, RD) cells with IC values of 26-87 μg/mL.
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| http://dx.doi.org/10.1080/14786419.2023.2167202 | DOI Listing |
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