AI Article Synopsis
- The study addresses the challenge of regenerating bone defects in clinical orthopaedics by creating a new bioactive material from stingray skin collagen and oyster shell powder.
- The newly developed stingray skin collagen/oyster osteoinductive composite scaffold (Col-OSP) features a three-dimensional porous structure and improved mechanical properties, making it suitable for bone tissue engineering.
- Laboratory tests show that the Col-OSP scaffold is non-toxic and enhances the proliferation, adhesion, and differentiation of bone cells while promoting the expression of important osteogenesis-related genes.
Article Abstract
The regeneration of bone defects is a major challenge for clinical orthopaedics. Herein, we designed and prepared a new type of bioactive material, using stingray skin collagen and oyster shell powder (OSP) as raw materials. A stingray skin collagen/oyster osteoinductive composite scaffold (Col-OSP) was prepared for the first time by genipin cross-linking, pore-forming and freeze-drying methods. These scaffolds were characterized by ATR-FTIR, SEM, compression, swelling, cell proliferation, cell adhesion, alkaline phosphatase activity, alizarin red staining and RT-PCR etc. The Col-OSP scaffold had an interconnected three-dimensional porous structure, and the mechanical properties of the Col-OSP composite scaffold were enhanced compared with Col, combining with the appropriate swelling rate and degradation rate, the scaffold was more in line with the requirements of bone tissue engineering scaffolds. The Col-OSP scaffold was non-toxic, promoted the proliferation, adhesion, and differentiation of MC3T3-E1 cells, and stimulated the osteogenesis-related genes expressions of osteocalcin (OCN), collagen type I (COL-I) and RUNX2 of MC3T3-E1 cells.
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| http://dx.doi.org/10.1080/09205063.2023.2166338 | DOI Listing |
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Article Synopsis
- The study addresses the challenge of regenerating bone defects in clinical orthopaedics by creating a new bioactive material from stingray skin collagen and oyster shell powder.
- The newly developed stingray skin collagen/oyster osteoinductive composite scaffold (Col-OSP) features a three-dimensional porous structure and improved mechanical properties, making it suitable for bone tissue engineering.
- Laboratory tests show that the Col-OSP scaffold is non-toxic and enhances the proliferation, adhesion, and differentiation of bone cells while promoting the expression of important osteogenesis-related genes.
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