AI Article Synopsis
- Lateral flow assays (LFA) effectively detect antibodies to SARS-CoV-2 proteins shortly after infection, and this study evaluated their performance in both immunocompetent adults and those with chronic inflammatory diseases post-vaccination.
- Results showed that LFA identified anti-S antibodies in 100% of immunocompetent participants and 87.3% of chronic inflammatory disease participants, with lower scores in immunosuppressed individuals.
- The study concludes that LFA presents a practical, low-resource method for antibody detection, making it valuable for outpatient settings compared to traditional laboratory analyses.
Article Abstract
Objective: Lateral flow assays (LFA) are sensitive for detecting antibodies to SARS-CoV-2 proteins within weeks after infection. This study tested samples from immunocompetent adults, and those receiving treatments for chronic inflammatory diseases (CID), before and after mRNA SARS-CoV-2 vaccination.
Methods: We compared results obtained with the COVIBLOCK Covid-19 LFA to those obtained by anti-spike (S) ELISA.
Results: The LFA detected anti-S antibodies in 29 of 29 (100%) of the immunocompetent and 110 of 126 (87.3%) of the CID participants after vaccination. Semiquantitative LFA scores were statistically significantly lower in samples from immunosuppressed participants, and were significantly correlated with anti-S antibody levels measured by ELISA.
Conclusions: This simple LFA test is a practical alternative to laboratory-based assays for detecting anti-S antibodies after infection or vaccination. This type of test may be most useful for testing people in outpatient or resource-limited settings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831968 | PMC |
| http://dx.doi.org/10.1016/j.jcvp.2023.100135 | DOI Listing |
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