A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Translocation t(6;9)(p22.3;q34) in myelodysplastic syndrome--refractory anemia with excess blasts. | LitMetric

AI Article Synopsis

  • A 69-year-old male patient with refractory anemia and excess blasts was diagnosed with a specific chromosomal abnormality, t(6;9)(p22.3;q34), found in his bone marrow and blood cells.
  • The abnormality t(6;9) has been linked to leukemia in other patients, some of whom had myelodysplastic syndrome (MDS) prior to developing acute non-lymphocytic leukemia (ANLL).
  • The patient's discovery of t(6;9) while still in the MDS stage indicates that this chromosomal change could be a significant factor in the progression from MDS to ANLL.

Article Abstract

A 69-year-old male patient with refractory anemia with excess blasts (RAEB) was found to have a consistent chromosomal abnormality, t(6;9)(p22.3;q34), in the bone marrow and unstimulated peripheral blood cells. Twenty patients with t(6;9) and leukemia have been reported; some of them had a myelodysplastic syndrome (MDS) before developing overt ANLL. Our patient was still in the MDS stage when the t(6;9) was found. This result suggests that t(6;9) represents one of the pathways from MDS to leukemia in patients with ANLL.

Download full-text PDF

Source
http://dx.doi.org/10.1016/0165-4608(87)90040-9DOI Listing

Publication Analysis

Top Keywords

anemia excess
8
excess blasts
8
translocation t69p223q34
4
t69p223q34 myelodysplastic
4
myelodysplastic syndrome--refractory
4
syndrome--refractory anemia
4
blasts 69-year-old
4
69-year-old male
4
male patient
4
patient refractory
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!