AI Article Synopsis
- Developed a method for Friedel-Crafts acylation using metal triflates in deep eutectic solvents, achieving good to excellent yields of ketone products.
- Conducted density functional theory calculations to understand the influence of different metals on the formation of active intermediate acylium triflate and the acidic conditions.
- Showed that metal triflates in deep eutectic solvents can be recovered and reused with minimal loss of catalytic activity.
Article Abstract
In this paper, we develop a method for Friedel-Crafts acylation using metal triflate in deep eutectic solvents. Various metal triflates were tested and provided good to excellent yields of corresponding ketone products. The density functional theory calculation revealed the metal effects on the formation of active intermediate acylium triflate as well as the acidic condition. The metal triflate in the deep eutectic solvent can be recovered and reused with a little loss in the catalytic activity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835085 | PMC |
| http://dx.doi.org/10.1021/acsomega.2c03944 | DOI Listing |
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