As the human immunodeficiency virus (HIV) infection has become a chronic disease, the question of becoming a parent arises for HIV-positive people. There are several answers to this question, depending on the situation. Here is an overview of the risks and possibilities of procreation with HIV.
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| http://dx.doi.org/10.1016/j.revinf.2022.12.012 | DOI Listing |
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Comprehensive assessment of the significance of cellular senescence-associated genes in neuroblastoma.
Genes Genomics
January 2025
Department of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan, China.
Background: The clinical course of high-risk neuroblastoma patients remains suboptimal, and the dynamic and reversible nature of cellular senescence provides an opportunity to develop new therapies.
Objective: This study aims to identify unique markers of cellular senescence in neuroblastoma and to explore their clinical significance.
Methods: The impact of multiple genetic regulatory mechanisms on cellular senescence-associated genes (CSAGs) was first assessed.
Cardiac Radiomics Analyses in Times of Photon-counting Computed Tomography for Personalized Risk Stratification in the Present and in the Future.
Rofo
January 2025
Department of Radiology and Nuclear Medicine, Heidelberg University Medical Faculty Mannheim, Mannheim, Germany.
The need for effective early detection and optimal therapy monitoring of cardiovascular diseases as the leading cause of death has led to an adaptation of the guidelines with a focus on cardiac computed tomography (CCTA) in patients with a low to intermediate risk of coronary heart disease (CHD). In particular, the introduction of photon-counting computed tomography (PCCT) in CT diagnostics promises significant advances through higher temporal and spatial resolution, and also enables advanced texture analysis, known as radiomics analysis. Originally developed in oncological imaging, radiomics analysis is increasingly being used in cardiac imaging and research.
View Article and Find Full Text PDFMachine Learning Potential for Identifying and Forecasting Complex Environmental Drivers of Infections in the United States.
Environ Health Perspect
January 2025
Centre for Environment, Fisheries and Aquaculture Science (CEFAS), Weymouth, UK.
Background: Environmental change in coastal areas can drive marine bacteria and resulting infections, such as those caused by , with both foodborne and nonfoodborne exposure routes and high mortality. Although ecological drivers of in the environment have been well-characterized, fewer models have been able to apply this to human infection risk due to limited surveillance.
Objectives: The Cholera and Other Illness Surveillance (COVIS) system database has reported infections in the United States since 1988, offering a unique opportunity to both explore the forecasting capabilities machine learning could provide and to characterize complex environmental drivers of infections.
Opportunities for More Tailored Approaches to Genotoxicity Testing and Carcinogenicity Strategy for Oligonucleotide Therapeutics: Outcome of an Industry Survey.
Nucleic Acid Ther
January 2025
Global Preclinical Safety, AbbVie Inc., North Chicago, Illinois, USA.
The Oligonucleotide Nonclinical Working Group (WG) of the European Federation of Pharmaceutical Industries and Associations conducted an industry survey to understand current practices and regulatory expectations for genotoxicity and carcinogenicity assessment of oligonucleotide therapeutics (ONTs), along with historical genotoxicity testing results. The survey, involving 29 pharmaceutical and biotechnology companies, revealed a consistent absence of genotoxicity across a diverse range of oligonucleotide classes and chemistries, consistent with previous observations. Despite the lack of genotoxicity, companies continue to follow standard testing guidelines, with only limited divergence.
View Article and Find Full Text PDFParent Reports of Developmental Service Utilization After Newborn Screening.
Int J Neonatal Screen
December 2024
RTI International, 3040 E. Cornwallis Road, Research Triangle Park, P.O. Box 12194, Research Triangle Park, NC 27709, USA.
Newborn screening (NBS) presents an opportunity to identify a subset of babies at birth who are at risk for developmental delays and could benefit from a range of developmental services. Potential developmental services in the United States include Part C Early Intervention (EI), private therapies, and school-based services. Using parent-reported outcomes, this study examined the rates at which a sample of children diagnosed with NBS conditions used each developmental service.
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