The potential of auto-antigen-guided treatment of immune checkpoint inhibitor-mediated myocarditis.

Med

Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

Published: January 2023

Immune checkpoint inhibitor (ICI)-mediated myocarditis is a rare but devastating side effect of cancer immunotherapy with up to 40% mortality and long-term cardiac issues such as arrhythmias and heart failure in affected patients. Recently, Axelrod et al. suggested an auto-antigen-driven mechanism as the immunological basis for this disease.

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http://dx.doi.org/10.1016/j.medj.2022.12.005DOI Listing

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