Background: The increase in paternal age and the percentage of births after assisted reproductive technologies (ART) may have consequences on offspring and society's position regarding access to ART must be questioned. Most countries recommend limiting ART to men under 60 years. What is the rationale for this threshold?
Objective: This systematic review assesses scientific arguments to establish links between paternal age, male fertility, and offspring health.
Material And Methods: Using the PRISMA guidelines, this systematic review of the literature analyzed 111 articles selected after screening PubMed, ScienceDirect, and Web of Science for articles published between January 1, 1995 and December 31, 2021.
Results: A strong correlation was highlighted between advanced paternal age and a decrease of some sperm parameters (semen volume and sperm motility) and infant morbidity (exponentially increased incidence of achondroplasia and Apert syndrome, and more moderately increased incidence of autism and schizophrenia). The impact of paternal age on pregnancy and fetal aneuploidy rates is more controversial. No association was found with spontaneous abortion rates.
Discussion And Conclusion: The scientific parameters should be explained to older parents undergoing ART. And for countries that discuss a limit on paternal age for access to ART, the debate requires consideration of social and ethical arguments.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/andr.13385 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sociocultural and perinatal health factors associated with Autism spectrum disorder (ASD) in children.
Compr Psychiatry
January 2025
School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia; Academic Unit of Child Psychiatry, Liverpool Hospital, Liverpool, NSW, Australia; Ingham Institute of Applied Medical Research and Liverpool Hospital, Sydney, NSW, Australia. Electronic address:
While previous research has examined perinatal factors in the context of Autism Spectrum Disorder (ASD), studies focusing on sociocultural factors is limited. We conducted a cross-sectional analysis utilizing data from the Australian Autism Biobank (AAB), which encompasses autistic children aged 2-17, their siblings, parents, and unrelated controls. Employing multivariable regression analyses, we aimed to identify factors associated with ASD across various domains, spanning health and lifestyle, perinatal, and postnatal contexts.
View Article and Find Full Text PDFMultilevel analysis of prevalence and determinants of diarrhea among under-five children in Somalia: insights from the Somalia demographic and health survey 2020.
BMC Public Health
January 2025
Faculty of Science and Humanities, School of Postgraduate Studies and Research (SPGSR), Amoud University, Borama, Somaliland.
Background: Diarrheal diseases remain a critical public health challenge, particularly for children under five in low- and middle-income countries such as Somalia. This study aimed to assess the prevalence and determinants of diarrhea in this vulnerable population, utilizing data from the 2020 Somalia Demographic and Health Survey.
Methods: This investigation employed secondary data from the 2020 Somalia Demographic and Health Survey.
Anthropometric and Sociodemographic Correlates of Dental Caries and Gingival Health in Children With Special Healthcare Needs at a Saudi Tertiary Care Hospital.
Spec Care Dentist
January 2025
Department of Prosthetic Dental Sciences, College of Dentistry, Qassim University, Qassim, Saudi Arabia.
Aims: To evaluate the impact of anthropometric and sociodemographic factors on dental caries and gingival health among children with special healthcare needs (SHCN).
Methods And Results: This cross-sectional study involved 108 children, aged 4-14 years, with congenital heart disease, childhood cancer, bleeding disorders, various syndromes, and multiple conditions. Caregivers completed a sociodemographic questionnaire, and children underwent dental examinations to assess caries, gingival health, and oral hygiene.
Paternal activation parenting and growth in children's inhibitory control across early childhood.
Soc Dev
February 2025
Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Activation parenting (AP) is a parenting construct derived from research and theory on paternal caregiving that includes behaviors that challenge children to approach novel situations, explore their environments, and take physical and socioemotional risks through a balance of encouragement and limit-setting. Although components of AP have been linked to different domains of children's self-regulation skills, comprehensive measures of AP and longitudinal research on families from low socioeconomic backgrounds are lacking. These limitations greatly constrain our understanding of the potential benefits of paternal AP for children's self-regulation development, including the maturation of inhibitory control (IC) in early childhood.
View Article and Find Full Text PDFMaternal smoking during infancy increases the risk of allergic diseases in children: a nationwide longitudinal survey in Japan.
Allergy Asthma Clin Immunol
January 2025
Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Background: The incidence of allergic diseases has been increasing in Japan. In particular, a serious decline in the age of onset of allergic rhinitis has been observed. Passive smoking from parental smoking has a significant impact on children's health; however, it is difficult to restrict smoking in the home.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!