In this study, two methods for wastewater treatment plant (WWTP) dimensioning were compared: (1) a traditional guideline-based approach, and (2) a mechanistic model-based approach. The design outputs depended on uncertainties in correlated influent concentrations, which emphasises the importance of uncertainty analysis. The results showed that model-based design could simplify and reduce the time required for uncertainty and sensitivity analysis compared to a conventional design approach, in which the equations are solved manually and iteratively. A benefit of the conventional design approach was the simple interpretation of which factors limited the design capacity. In the end, this study shows the potential, as well as the need for, model-based design of WWTPs.
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http://dx.doi.org/10.2166/wst.2022.426 | DOI Listing |
Stat Med
February 2025
MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
There is a growing number of Phase I dose-finding studies that use a model-based approach, such as the CRM or the EWOC method to estimate the dose-toxicity relationship. It is common to assume that all patients will have similar toxicity risk given the dose regardless of patients' individual characteristics. In many trials, however, some patients' covariates (e.
View Article and Find Full Text PDFJ Acoust Soc Am
January 2025
School of Civil and Transportation Engineering, Guangdong University of Technology, Guangzhou 510006, China.
Since traffic flow has not been generated, a traffic noise prediction model based on actual traffic state data cannot be directly applied to the planned road network. Therefore, a regional traffic noise prediction method is proposed to find the upper limit of network noise emission based on design elements. The model is developed with noise predictions of the basic road section, interrupted/continuous intersections, and regional network.
View Article and Find Full Text PDFBehav Sci (Basel)
December 2024
Smart Design Lab, School of Design, Northumbria University, Newcastle upon Tyne NE1 8ST, UK.
Nostalgic scenes can trigger nostalgia to a considerable extent and can be effectively used as a nostalgic trigger that contributes to the psychological comfort of the elderly and immigrant populations, but a design system has not been adequately studied. Therefore, the design principles and digital twin (DT) design system of nostalgic scenes is proposed in this study. It focuses on the construction of a nostalgic scene DT model based on the system of system (SoS) theory.
View Article and Find Full Text PDFJMIR Aging
January 2025
Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China, 86 13601893105.
Background: Serum levels of silent information regulator 6 (SIRT6), a key biomarker of aging, were identified as a predictor of coronary artery disease (CAD), but whether SIRT6 can distinguish severity of coronary artery lesions in older adult patients is unknown.
Objectives: This study developed a nomogram to demonstrate the functionality of SIRT6 in assessing severity of coronary artery atherosclerosis.
Methods: Patients aged 60 years and older with angina pectoris were screened for this single-center clinical study between October 1, 2022, and March 31, 2023.
Front Psychol
January 2025
Department of Psychology, Rey Juan Carlos University, Alcorcón, Spain.
Introduction: Suffering from chronic pain (CP) and coping with parenthood can be challenging for parental mental health. Pain can hinder the ability to deal with demands related to parenthood, which can negatively affect their psychological well-being because of unmet caregiving expectations.
Methods: Considering the limited amount of research regarding the mental health of parents with CP, the study's main aim was to test a predictive model based on previous scientific literature, using structural equation analysis, in which parental competence and parental guilt partially mediate the relationship between parental stress and depression.
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