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Control of protein stability by post-translational modifications. | LitMetric

Control of protein stability by post-translational modifications.

Nat Commun

Creative Research Initiatives Center for Epigenetic Code and Diseases, School of Biological Sciences, Seoul National University, Seoul, 08826, Korea.

Published: January 2023

AI Article Synopsis

Article Abstract

Post-translational modifications (PTMs) can occur on specific amino acids localized within regulatory domains of target proteins, which control a protein's stability. These regions, called degrons, are often controlled by PTMs, which act as signals to expedite protein degradation (PTM-activated degrons) or to forestall degradation and stabilize a protein (PTM-inactivated degrons). We summarize current knowledge of the regulation of protein stability by various PTMs. We aim to display the variety and breadth of known mechanisms of regulation as well as highlight common themes in PTM-regulated degrons to enhance potential for identifying novel drug targets where druggable targets are currently lacking.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839724PMC
http://dx.doi.org/10.1038/s41467-023-35795-8DOI Listing

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